{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:08:55Z","timestamp":1791119335237,"version":"4.1.0"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5062","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1992,6,5]]},"abstract":"<jats:p>\n            Vertebrate T cells express either an \u03b1\u03b2 or \u03b3\u03b4 T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. \u03b1\u03b2\n            <jats:sup>+<\/jats:sup>\n            T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of \u03b1\u03b2\n            <jats:sup>+<\/jats:sup>\n            T cells on B cell development is poorly understood. To investigate the developmental effects of \u03b1\u03b2\n            <jats:sup>+<\/jats:sup>\n            T cells on B cells and \u03b3\u03b4\n            <jats:sup>+<\/jats:sup>\n            T cells, mice homozygous for a disrupted TCR\u03b1 gene were generated. The homozygotes showed elimination of \u03b1\u03b2\n            <jats:sup>+<\/jats:sup>\n            T cells and the loss of thymic medullae. Despite this, \u03b3\u03b4\n            <jats:sup>+<\/jats:sup>\n            T cells developed in normal numbers, and there was an increase in splenic B cells.\n          <\/jats:p>","DOI":"10.1126\/science.1604321","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:03:06Z","timestamp":1160089386000},"page":"1448-1452","source":"Crossref","is-referenced-by-count":271,"title":["Lymphoid Development in Mice Congenitally Lacking T Cell Receptor \u03b1\u03b2-Expressing Cells"],"prefix":"10.1126","volume":"256","author":[{"given":"Karen L.","family":"Philpott","sequence":"first","affiliation":[{"name":"Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L.","family":"Viney","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Kay","sequence":"additional","affiliation":[{"name":"Section of Comparative Biology, Medical Research Council Clinical Research Centre, Harrow, Middlesex HA1 3UJ, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohaila","family":"Rastan","sequence":"additional","affiliation":[{"name":"Section of Comparative Biology, Medical Research Council Clinical Research Centre, Harrow, Middlesex HA1 3UJ, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith M.","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Department of Biology, Kline Biology Tower, Yale University, New Haven, CT 06511."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Biology, Kline Biology Tower, Yale University, New Haven, CT 06511."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C.","family":"Hayday","sequence":"additional","affiliation":[{"name":"Department of Biology, Kline Biology Tower, Yale University, New Haven, CT 06511."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Owen","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(89)90502-3","volume":"58","year":"1989","unstructured":"BERG, L.J., ANTIGEN MHC-SPECIFIC T-CELLS ARE PREFERENTIALLY EXPORTED FROM THE THYMUS IN THE PRESENCE OF THEIR MHC LIGAND, CELL 58: 1035 (1989).","journal-title":"CELL"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/342931a0","volume":"342","year":"1989","unstructured":"BONNEVILLE, M, BLOCKAGE OF ALPHA-BETA T-CELL DEVELOPMENT BY TCR GAMMA-DELTA TRANSGENES, NATURE 342: 931 (1989).","journal-title":"NATURE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1695022"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/322145a0","volume":"322","year":"1986","unstructured":"BRENNER, M.B., IDENTIFICATION OF A PUTATIVE 2ND T-CELL RECEPTOR, NATURE 322: 145 (1986).","journal-title":"NATURE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Butcher E. 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