{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:16:30Z","timestamp":1761862590220},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3869","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1969,2,21]]},"abstract":"<jats:p>\n            Mosquitoes (\n            <jats:italic>Aedes aegypti<\/jats:italic>\n            ) were reared aseptically for one generation on an artificial diet containing neither vitamin A nor its usual precursor in animals, \u03b2-carotene. Function (electrical response to light) in the compound eyes of these animals was severely impaired. Ultrastructure of the photoreceptor cells was abnormal in two respects: multivesicular bodies were absent, and masses of smooth membrane lamellae were present near the nucleus. The organization of the photoreceptor organelle, the rhabdomere, was normal. The eyes of control mosquitoes, to whose diet \u03b2-carotene was added, were functionally and structurally normal. Multivesicular bodies were normally abundant and the perinuclear membrane masses were not present.\n          <\/jats:p>","DOI":"10.1126\/science.163.3869.821","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:14:21Z","timestamp":1160050461000},"page":"821-823","source":"Crossref","is-referenced-by-count":36,"title":["Vitamin A Deficiency: Effect on Mosquito Eye Ultrastructure"],"prefix":"10.1126","volume":"163","author":[{"given":"J. D.","family":"Brammer","sequence":"first","affiliation":[{"name":"USAF School of Aerospace Medicine, Box 4323, Brooks AFB, Texas 78235"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University, Lafaoyette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0022-1910(62)90035-5","volume":"8","year":"1962","unstructured":"AKOV, S, A QUALITATIVE AND QUANTITATIVE STUDY OF THE NUTRITIONAL REQUIREMENTS OF AEDES-AEGYPTI L LARVAE, JOURNAL OF INSECT PHYSIOLOGY 8: 319 (1962).","journal-title":"JOURNAL OF INSECT PHYSIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.158.3798.268"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/jcp.1030620107","volume":"62","year":"1963","unstructured":"COHEN, C.F., VITAMIN A CONTENT AND SPECTRAL RESPONSE OF HOUSE FLIES REARED ON DIETS WITH AND WITHOUT A VITAMIN A SOURCE, JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY 62: 43 (1963).","journal-title":"JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY"},{"key":"e_1_2_1_4_1","first-page":"186","year":"1967","unstructured":"Dowling, J. 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