{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:56:33Z","timestamp":1758279393132},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3892","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1969,8]]},"abstract":"<jats:p>The nuclear fraction of a homogenate of anterior pituitary has a marked binding affinity for estradiol but not for other hormonal steroids. Characteristics of the uptake of estradiol by pituitary nuclear fraction are like those reported for the uterus. Study in vitro will be useful in elucidating how direct estrogen feedback control of anterior pituitary function is mediated.<\/jats:p>","DOI":"10.1126\/science.165.3892.496","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:14:21Z","timestamp":1160050461000},"page":"496-498","source":"Crossref","is-referenced-by-count":23,"title":["Estradiol: Specific Binding by Pituitary Nuclear Fraction in vitro"],"prefix":"10.1126","volume":"165","author":[{"given":"W. W.","family":"Leavitt","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Friend","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"AXELROD L.R. ACTA ENDOCRINOLOGICA 99 (1965)."},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1210\/endo-73-6-696","volume":"73","year":"1963","unstructured":"BOGDANOVE, E.M., DIRECT GONAD-PITUITARY FEEDBACK - AN ANALYSIS OF EFFECTS OF INTRACRANIAL ESTROGENIC DEPOTS ON GONADOTROPHIN SECRETION, ENDOCRINOLOGY 73: 696 (1963).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0083-6729(08)60340-4","volume":"22","year":"1964","unstructured":"BOGDANOVE, E. M., VITAMINS AND HORMONES 22: 205 (1964).","journal-title":"VITAMINS AND HORMONES"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0039-128X(67)90004-9","volume":"10","year":"1967","unstructured":"BRECHER, P. I., STEROIDS 10: 635 (1967).","journal-title":"STEROIDS"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1210\/endo-48-2-133","volume":"48","year":"1951","unstructured":"BYRNES, W.W., THE INHIBITION OF GONADOTROPHIC HORMONE SECRETION BY PHYSIOLOGICAL DOSES OF ESTROGEN, ENDOCRINOLOGY 48: 133 (1951).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1210\/endo-49-4-449","volume":"49","year":"1951","unstructured":"BYRNES, W.W., EFFECT OF PHYSIOLOGICAL AMOUNTS OF ESTROGEN ON THE SECRETION OF FOLLICLE STIMULATING AND LUTEINIZING HORMONES, ENDOCRINOLOGY 49: 449 (1951).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1210\/endo-79-1-38","volume":"79","year":"1966","unstructured":"EISENFELD, A.J., EFFECT OF STEROID HORMONES OVARIECTOMY ESTROGEN PRETREATMENT SEX AND IMMATURITY ON DISTRIBUTION OF 3H-ESTRADIOL, ENDOCRINOLOGY 79: 38 (1966).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3842.649"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.2.632"},{"key":"e_1_2_1_10_1","first-page":"387","volume":"18","year":"1962","unstructured":"JENSEN, E.V., BASIC GUIDES TO THE MECHANISM OF ESTROGEN ACTION, RECENT PROGRESS IN HORMONE RESEARCH 18: 387 (1962).","journal-title":"RECENT PROGRESS IN HORMONE RESEARCH"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1210\/endo-80-4-567","volume":"80","year":"1967","unstructured":"KATO, J, PREFERENTIAL UPTAKE OF ESTRADIOL BY ANTERIOR HYPOTHALAMUS OF RAT, ENDOCRINOLOGY 80: 567 (1967).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1210\/endo-80-6-1133","volume":"80","year":"1967","unstructured":"KATO, J, FACTORS AFFECTING UPTAKE OF ESTRADIOL-6 7-3H BY HYPOPHYSIS AND HYPOTHALAMUS, ENDOCRINOLOGY 80: 1133 (1967).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1677\/joe.0.0320009","volume":"32","year":"1965","unstructured":"KING, RJB, INTRACELLULAR LOCALIZATION OF OESTROGEN IN RAT TISSUES, JOURNAL OF ENDOCRINOLOGY 32: 9 (1965).","journal-title":"JOURNAL OF ENDOCRINOLOGY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1677\/joe.0.0410223","volume":"41","year":"1968","unstructured":"KING, RJB, LOCATION OF [6,7-3H]OESTRADIOL-17BETA IN MOUSE VAGINA, JOURNAL OF ENDOCRINOLOGY 41: 223 (1968).","journal-title":"JOURNAL OF ENDOCRINOLOGY"},{"key":"e_1_2_1_15_1","first-page":"497","volume":"61","year":"1968","unstructured":"MCGUIRE, J.L., ESTROGEN RECEPTORS IN INTACT RAT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 61: 497 (1968).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endo-75-1-1","volume":"75","year":"1964","unstructured":"PARLOW, A.F., DIFFERENTIAL ACTION OF SMALL DOSES OF ESTRADIOL ON GONADOTROPHINS IN RAT, ENDOCRINOLOGY 75: 1 (1964).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_17_1","unstructured":"Robinson J. A. in preparation.."},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1210\/endo-84-1-108","volume":"84","year":"1969","unstructured":"ROCHEFORT, H, NEW IN VITRO STUDIES OF ESTRADIOL BINDING IN CASTRATED RAT UTERUS, ENDOCRINOLOGY 84: 108 (1969).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/4.1.1","volume":"4","year":"1956","unstructured":"SCOTT, J.F., STUDIES IN HISTOCHEMISTRY .1. DETERMINATION OF NUCLEIC ACIDS IN MICROGRAM AMOUNTS OF TISSUE, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 4: 1 (1956).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-83-4-777"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/14.3.274","volume":"14","year":"1966","unstructured":"STUMPF, W.E., HIGH RESOLUTION AUTORADIOGRAPHY WITH DRY MOUNTED FREEZE-DRIED FROZEN SECTIONS - COMPARATIVE STUDY OF 6 METHODS USING 2 DIFFUSIBLE COMPOUNDS 3H-ESTRADIOL AND 3H-MESOBILIRUBINOGEN, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 14: 274 (1966).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3857.1001"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00339399","volume":"92","year":"1968","unstructured":"STUMPF, W.E., CELLULAR AND SUBCELLULAR 3H-ESTRADIOL LOCALIZATION IN PITUITARY BY AUTORADIOGRAPHY, ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE 92: 23 (1968).","journal-title":"ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.165.3892.496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:15:51Z","timestamp":1704989751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.165.3892.496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,8]]},"references-count":23,"journal-issue":{"issue":"3892","published-print":{"date-parts":[[1969,8]]}},"alternative-id":["10.1126\/science.165.3892.496"],"URL":"https:\/\/doi.org\/10.1126\/science.165.3892.496","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,8]]}}}