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These two mothers also had reduced hypoxanthine-guanine phosphoribosyltransferase activity and increased adenine phosphoribosyltransferase activity in erythrocyte lysates. All three mothers showed an abnormal increase in urate production, as judged by the rate of incorporation of glycine into urate.<\/jats:p>","DOI":"10.1126\/science.166.3912.1533","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:14:21Z","timestamp":1160050461000},"page":"1533-1535","source":"Crossref","is-referenced-by-count":39,"title":["Purine Metabolism in Heterozygous Carriers of Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency"],"prefix":"10.1126","volume":"166","author":[{"given":"B. T.","family":"Emmerson","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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