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These antibodies were rarely present in other serums even though some of them showed high titers of antibodies to Epstein-Barr virus when assayed on EB3 Burkitt tumor cells; they also prevented synthesis of early antigens, provided the serums were mixed with the virus prior to inoculation. Antibodies to early antigens possibly reflect current or recent disease processes that are associated with the virus.<\/jats:p>","DOI":"10.1126\/science.169.3941.188","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:56:56Z","timestamp":1160053016000},"page":"188-190","source":"Crossref","is-referenced-by-count":476,"title":["Differential Reactivity of Human Serums with Early Antigens Induced by Epstein-Barr Virus"],"prefix":"10.1126","volume":"169","author":[{"given":"Werner","family":"Henle","sequence":"first","affiliation":[{"name":"Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia 19146"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gertrude","family":"Henle","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia 19146"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Zajac","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia 19146"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Pearson","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia 19146"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Waubke","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia 19146"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Scriba","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia 19146"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF02618214","volume":"4","year":"1969","unstructured":"DIEHL, V, IN VITRO 4: 92 (1969).","journal-title":"IN VITRO"},{"key":"e_1_2_1_2_1","first-page":"133","volume":"44","year":"1970","unstructured":"DUNKEL, V.C., STUDIES ON RELATION OF MEMBRANE IMMUNOFLUORESCENCE TO EPSTEIN-BARR VIRUS INFECTION, JOURNAL OF THE NATIONAL CANCER INSTITUTE 44: 133 (1970).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_3_1","first-page":"547","volume":"37","year":"1966","unstructured":"EPSTEIN, M.A., MORPHOLOGICAL AND VIROLOGICAL INVESTIGATIONS ON CULTURED BURKITT TUMOR LYMPHOBLASTS (STRAIN RAJI), JOURNAL OF THE NATIONAL CANCER INSTITUTE 37: 547 (1966).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_4_1","first-page":"69","volume":"4","year":"1965","unstructured":"EPSTEIN, M.A., WISTAR INSTITUTE SYMPOSIUM MONOGRAPH 4: 69 (1965).","journal-title":"WISTAR INSTITUTE SYMPOSIUM MONOGRAPH"},{"key":"e_1_2_1_5_1","first-page":"740","volume":"63","year":"1969","unstructured":"GERBER, P, TRANSFORMATION AND CHROMOSOME CHANGES INDUCED BY EPSTEIN-BARR VIRUS IN NORMAL HUMAN LEUKOCYTE CULTURES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 63: 740 (1969).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1128\/jb.91.3.1248-1256.1966","volume":"91","year":"1966","unstructured":"HENLE, G, IMMUNOFLUORESCENCE IN CELLS DERIVED FROM BURKITTS LYMPHOMA, JOURNAL OF BACTERIOLOGY 91: 1248 (1966).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/jb.92.1.269-271.1966","volume":"92","year":"1966","unstructured":"HENLE, W, ANTIBODY COATING AND AGGLUTINATION OF VIRUS PARTICLES SEPARATED FROM EB3 LINE OF BURKITT LYMPHOMA CELLS, JOURNAL OF BACTERIOLOGY 92: 269 (1966).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_8_1","first-page":"105","volume":"6","year":"1968","unstructured":"Henle, W., Perspectives in Virology 6: 105 (1968).","journal-title":"Perspectives in Virology"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3792.1064"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1128\/jvi.1.5.1045-1051.1967","volume":"1","year":"1967","unstructured":"HINUMA, Y, J VIROL 1: 1045 (1967).","journal-title":"J VIROL"},{"key":"e_1_2_1_11_1","unstructured":"Horoszewicz J. 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