{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:02:32Z","timestamp":1790805752900,"version":"4.1.0"},"reference-count":13,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3952","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1970,9,25]]},"abstract":"<jats:p>We have analyzed 88 pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used. The possibility that recessive mutations have been induced but were undetected cannot be evaluated definitively at present.<\/jats:p>","DOI":"10.1126\/science.169.3952.1326","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:56:56Z","timestamp":1160053016000},"page":"1326-1327","source":"Crossref","is-referenced-by-count":100,"title":["Pregnancies after Chemotherapy of Trophoblastic Neoplasms"],"prefix":"10.1126","volume":"169","author":[{"given":"David H.","family":"Van Thiel","sequence":"first","affiliation":[{"name":"National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griff T.","family":"Ross","sequence":"additional","affiliation":[{"name":"National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mortimer B.","family":"Lipsett","sequence":"additional","affiliation":[{"name":"National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1749-6632.1958.tb42637.x","volume":"68","year":"1958","unstructured":"AUERBACH, C, MUTAGENIC EFFECTS OF ALKYLATING AGENTS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 68: 731 (1958).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9378(65)90584-3","volume":"91","year":"1965","unstructured":"BIERMAN, J.M., ANALYSIS OF OUTCOME OF ALL PREGNANCIES IN A COMMUNITY, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 91: 37 (1965).","journal-title":"AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2307\/4591959","volume":"78","year":"1963","unstructured":"BIERMAN, J.M., THE COMMUNITY IMPACT OF HANDICAPS OF PRENATAL OR NATAL ORIGIN, PUBLIC HEALTH REPORTS 78: 839 (1963).","journal-title":"PUBLIC HEALTH REPORTS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1651-2227.1970.tb09007.x","volume":"59","year":"1970","unstructured":"EKELUND, H, MAJOR AND MINOR MALFORMATIONS IN NEWBORNS AND INFANTS UP TO 1 YEAR OF AGE, ACTA PAEDIATRICA SCANDINAVICA 59: 297 (1970).","journal-title":"ACTA PAEDIATRICA SCANDINAVICA"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0002-9378(61)90283-6","volume":"82","year":"1961","unstructured":"HERTZ, R, 5 YEARS EXPERIENCE WITH CHEMOTHERAPY OF METASTTATIC CHORIOCARCINOMA AND RELATED TROPHOBLASTIC TUMORS IN WOMEN, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 82: 631 (1961).","journal-title":"AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0002-9378(16)35198-5","volume":"86","year":"1963","unstructured":"HERTZ, R, PRIMARY CHEMOTHERAPY OF NONMETASTATIC TROPHOBLASTIC DISEASE IN WOMEN, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 86: 808 (1963).","journal-title":"AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY"},{"key":"e_1_2_1_7_1","first-page":"1222","volume":"48","year":"1962","unstructured":"HURWITZ, J, ROLE OF DEOXYRIBONUCLEIC ACID IN RIBONUCLEIC ACID SYNTHESIS, .3. INHIBITION OF ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID BY ACTINOMYCIN D AND PROFLAVIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 48: 1222 (1962).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1749-6632.1958.tb42639.x","volume":"68","year":"1958","unstructured":"MURPHY, M.L., THE COMPARATIVE EFFECTS OF 5 POLYFUNCTIONAL ALKYLATING AGENTS ON THE RAT FETUS, WITH ADDITIONAL NOTES ON THE CHICK EMBRYO, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 68: 762 (1958).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1471-0528.1968.tb02083.x","volume":"75","year":"1968","unstructured":"NICHOLSON, H.O., JOURNAL OF OBSTETRICS AND GYNAECOLOGY OF THE BRITISH COMMONWEALTH 75: 307 (1968).","journal-title":"JOURNAL OF OBSTETRICS AND GYNAECOLOGY OF THE BRITISH COMMONWEALTH"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(65)90661-7","volume":"93","year":"1965","unstructured":"ROSS, G.T., SEQUENTIAL USE OF METHOTREXATE AND ACTINOMYCIN D IN TREATMENT OF METASTATIC CHORIOCARCINOMA AND RELATED TROPHOBLASTIC DISEASES IN WOMEN, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 93: 223 (1965).","journal-title":"AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/00003081-196706000-00006","volume":"10","year":"1967","unstructured":"ROSS, G. T., CLINICAL OBSTETRICS AND GYNECOLOGY 10: 323 (1967).","journal-title":"CLINICAL OBSTETRICS AND GYNECOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1001\/jama.1960.63020160002008","volume":"172","year":"1960","unstructured":"SOKAL, J.E., EFFECTS OF CANCER CHEMOTHERAPEUTIC AGENTS ON THE HUMAN FETUS, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 172: 1765 (1960).","journal-title":"JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0002-9378(15)33712-1","volume":"100","year":"1968","unstructured":"STICKLE, G, DEFECTIVE DEVELOPMENT AND REPRODUCTIVE WASTAGE IN UNITED STATES, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 100: 442 (1968).","journal-title":"AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.169.3952.1326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:55:28Z","timestamp":1704992128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.169.3952.1326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,9,25]]},"references-count":13,"journal-issue":{"issue":"3952","published-print":{"date-parts":[[1970,9,25]]}},"alternative-id":["10.1126\/science.169.3952.1326"],"URL":"https:\/\/doi.org\/10.1126\/science.169.3952.1326","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,9,25]]}}}