{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:11:22Z","timestamp":1776705082456,"version":"3.51.2"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3952","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1970,9,25]]},"abstract":"<jats:p>\n            Vitamin B\n            <jats:sub>6<\/jats:sub>\n            deficiency was induced in pregnant rats with a deficient diet and with 4-deoxypyridoxine, a B\n            <jats:sub>6<\/jats:sub>\n            antagonist. Treated animals developed typical skin changes of B\n            <jats:sub>6<\/jats:sub>\n            deficiency. Fetuses were small and appeared anemic. Major fetal malformations were omphalocele, exencephaly, cleft palate, micrognathia, digital defects, and splenic hypoplasia. This teratologic system was developed as a model for human syndromes that exhibit combined immunologic and neurologic or skeletal defects.\n          <\/jats:p>","DOI":"10.1126\/science.169.3952.1329","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:56:56Z","timestamp":1160053016000},"page":"1329-1330","source":"Crossref","is-referenced-by-count":65,"title":["Teratogenicity of Vitamin B\n            <sub>6<\/sub>\n            Deficiency: Omphalocele, Skeletal and Neural Defects, and Splenic Hypoplasia"],"prefix":"10.1126","volume":"169","author":[{"given":"Starkey D.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Washington School of Medicine, Seattle 98105"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington School of Medicine, Seattle 98105"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Shepard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington School of Medicine, Seattle 98105"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"612","year":"1968","unstructured":"Axelrod, A. 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