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Atropine and methscopolamine, parasympathetic blocking agents, prevented conditional but not allergic attacks; diphenhydramine, an antihistamine, prevented allergic attacks; and methysergide, which blocks serotonin (which is believed to trigger human asthma), prevented neither. The guinea pig's allergic reaction is probably the result of a bronchospasm induced by histamine released in tissue of the airway by a local combination of allergen and antibody. The conditional attack is believed to be a constriction of the airway mediated by parasympathetic fibers of central origin.<\/jats:p>","DOI":"10.1126\/science.170.3960.864","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T12:56:56Z","timestamp":1160053016000},"page":"864-866","source":"Crossref","is-referenced-by-count":31,"title":["Pharmacological Differentiation of Allergic and Classically Conditioned Asthma in the Guinea Pig"],"prefix":"10.1126","volume":"170","author":[{"given":"Don R.","family":"Justesen","sequence":"first","affiliation":[{"name":"Neuropsychology Laboratories, Veterans Administration Hospital, Kansas City, Missouri 64128"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Braun","sequence":"additional","affiliation":[{"name":"Surgical Service, Veterans Administration Hospital, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Garrison","sequence":"additional","affiliation":[{"name":"Microbiology Laboratories, Veterans Administration Hospital, Kansas City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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