{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:20:28Z","timestamp":1770999628980,"version":"3.50.1"},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3969","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1971,1,29]]},"abstract":"<jats:p>Mice were injected twice a day for 4 days with saline or phenobarbital or ethanol. Treatment with phenobarbital, but not ethanol, increased the amount of liver acetaldehyde dehydrogenase activity. More rapid removal of acetaldehyde, which is a toxic metabolic intermediate of ethanol, may contribute to the alcohol tolerance exhibited by persons who use barbiturates regularly.<\/jats:p>","DOI":"10.1126\/science.171.3969.387","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"387-389","source":"Crossref","is-referenced-by-count":44,"title":["Induction of Liver Acetaldehyde Dehydrogenase: Possible Role in Ethanol Tolerance after Exposure to Barbiturates"],"prefix":"10.1126","volume":"171","author":[{"given":"Geoffrey","family":"Redmond","sequence":"first","affiliation":[{"name":"Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Cohen","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.167.3926.1749"},{"key":"e_1_2_1_2_1","first-page":"317","volume":"19","year":"1967","unstructured":"CONNEY, A.H., PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION, PHARMACOLOGICAL REVIEWS 19: 317 (1967).","journal-title":"PHARMACOLOGICAL REVIEWS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bj0950311","volume":"95","year":"1965","unstructured":"DALZIEL, K, ACTIVITY OF LIVER ALCOHOL DEHYDROGENASE WITH NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE AS COENZYME, BIOCHEMICAL JOURNAL 95: 311 (1965).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.167.3920.1005"},{"key":"e_1_2_1_5_1","first-page":"298","volume":"12","year":"1970","unstructured":"DEITRICH, R.A., PHARMACOLOGIST 12: 298 (1970).","journal-title":"PHARMACOLOGIST"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/0006-2952(69)90164-6","volume":"18","year":"1969","unstructured":"GOLDBERG, L, INHIBITION OF ETHANOL METABOLISM IN VIVO BY ADMINISTRATION OF PYRAZOLE, BIOCHEMICAL PHARMACOLOGY 18: 1749 (1969).","journal-title":"BIOCHEMICAL PHARMACOLOGY"},{"key":"e_1_2_1_7_1","first-page":"288","year":"1965","unstructured":"JAFFE, J.H., PHARMACOLOGICAL BASI: 288 (1965).","journal-title":"PHARMACOLOGICAL BASI"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0021-9258(18)64238-3","volume":"236","year":"1961","unstructured":"MAXWELL, E.S., STEROID-SENSITIVE ALDEHYDE DEHYDROGENASE FROM RABBIT LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 236: 1032 (1961).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_9_1","first-page":"275","volume":"29","year":"1970","unstructured":"REDMOND, G, FEDERATION PROCEEDINGS 29: 275 (1970).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_10_1","first-page":"276","year":"1962","unstructured":"REMMER, H, ENZYMES DRUG ACTION: 276 (1962).","journal-title":"ENZYMES DRUG ACTION"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1037\/h0040350","volume":"56","year":"1963","unstructured":"RODGERS, D.A., ALCOHOL PREFERENCE AS A FUNCTION OF ITS CALORIC UTILITY IN MICE, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 56: 666 (1963).","journal-title":"JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3854.690"},{"key":"e_1_2_1_13_1","first-page":"537","volume":"338","year":"1963","unstructured":"THEORELL, H, LIVER ALCOHOL DEHYDROGENASE-DPN-PYRAZOLE COMPLEX - A MODEL OF A TERNARY INTERMEDIATE IN ENZYME REACTION, BIOCHEMISCHE ZEITSCHRIFT 338: 537 (1963).","journal-title":"BIOCHEMISCHE ZEITSCHRIFT"},{"key":"e_1_2_1_14_1","first-page":"61","year":"1966","unstructured":"TRUITT, E.B., BIOCH FACTORS ALCOHO: 61 (1966).","journal-title":"BIOCH FACTORS ALCOHO"},{"key":"e_1_2_1_15_1","unstructured":"TRUITT E.B. BIOLOGY ALCOHOLISM 1:."},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0021-9258(18)72234-5","volume":"149","year":"1943","unstructured":"WESTERFELD, W.W., The coupled oxidation-reduction of alcohol and pyruvate in vivo, JOURNAL OF BIOLOGICAL CHEMISTRY 149: 237 (1943).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.171.3969.387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:19:52Z","timestamp":1704989992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.171.3969.387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,1,29]]},"references-count":16,"journal-issue":{"issue":"3969","published-print":{"date-parts":[[1971,1,29]]}},"alternative-id":["10.1126\/science.171.3969.387"],"URL":"https:\/\/doi.org\/10.1126\/science.171.3969.387","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,1,29]]}}}