{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:44:14Z","timestamp":1762271054024},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3969","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1971,1,29]]},"abstract":"<jats:p>\n            The frequency of carriers of the\n            <jats:italic>P<\/jats:italic>\n            <jats:sup>a<\/jats:sup>\n            and\n            <jats:italic>P<\/jats:italic>\n            <jats:sup>c<\/jats:sup>\n            alleles of the gene for acid phosphatase in the erythrocyte is significantly higher in male subjects deficient in glucose-6-phosphate dehydrogenase and having hemolytic clinical favism than it is in the general population. This observation seems to indicate that alleles (\n            <jats:italic>P<\/jats:italic>\n            <jats:sup>a<\/jats:sup>\n            and\n            <jats:italic>P<\/jats:italic>\n            <jats:sup>c<\/jats:sup>\n            ) of a gene polymorphic in all human populations affect the fitness of the involved phenotypes in special genotypic and nongenotypic conditions.\n          <\/jats:p>","DOI":"10.1126\/science.171.3969.409","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"409-411","source":"Crossref","is-referenced-by-count":44,"title":["Favism: Association with Erythrocyte Acid Phosphatase Phenotype"],"prefix":"10.1126","volume":"171","author":[{"given":"Egidio","family":"Bottini","sequence":"first","affiliation":[{"name":"Centro di Genetica Evoluzionistica del CNR (Istituto di Genetica della Facolt\u00e0 di Scienze) and Clinica Pediatrica dell'Universit\u00e0 di Roma, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Lucarelli","sequence":"additional","affiliation":[{"name":"Centro di Genetica Evoluzionistica del CNR (Istituto di Genetica della Facolt\u00e0 di Scienze) and Clinica Pediatrica dell'Universit\u00e0 di Roma, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Agostino","sequence":"additional","affiliation":[{"name":"Centro di Genetica Evoluzionistica del CNR (Istituto di Genetica della Facolt\u00e0 di Scienze) and Clinica Pediatrica dell'Universit\u00e0 di Roma, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricciotti","family":"Palmarino","sequence":"additional","affiliation":[{"name":"Centro di Genetica Evoluzionistica del CNR (Istituto di Genetica della Facolt\u00e0 di Scienze) and Clinica Pediatrica dell'Universit\u00e0 di Roma, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Businco","sequence":"additional","affiliation":[{"name":"Centro di Genetica Evoluzionistica del CNR (Istituto di Genetica della Facolt\u00e0 di Scienze) and Clinica Pediatrica dell'Universit\u00e0 di Roma, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Antognoni","sequence":"additional","affiliation":[{"name":"Centro di Genetica Evoluzionistica del CNR (Istituto di Genetica della Facolt\u00e0 di Scienze) and Clinica Pediatrica dell'Universit\u00e0 di Roma, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"115","volume":"29","year":"1960","unstructured":"BERNINI, L, ACCADEMIA NAZIONALE 29: 115 (1960).","journal-title":"ACCADEMIA NAZIONALE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0006-291X(64)90394-8","volume":"17","year":"1964","unstructured":"BOTTINI, E, EFFECT OF OXIDIZED GLUTATHIONE ON HUMAN RED CELL ACID PHOSPHATASES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 17: 260 (1964).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_3_1","first-page":"379","volume":"21","year":"1965","unstructured":"BOTTINI, E, ACID PHOSPHATASES AND HEMOGLOBIN IN NORMAL AND G-6-PD DEFICIENT ERYTHROCYTES INCUBATED WITH ACETYLPHENYLHYDRAZINE UNDER VARIOUS CONDITIONS, EXPERIENTIA 21: 379 (1965).","journal-title":"EXPERIENTIA"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF02135945","volume":"23","year":"1967","unstructured":"BOTTINI, E, DIFFERENTIAL EFFECT OF OXIDIZED GLUTATHIONE OR ACETYLPHENYLHYDRAZINE ON INDIVIDUAL ELECTROPHORETIC COMPONENTS OF RED CELL ACID PHOSPHATASES, EXPERIENTIA 23: 107 (1967).","journal-title":"EXPERIENTIA"},{"key":"e_1_2_1_5_1","first-page":"141","volume":"16","year":"1964","unstructured":"HOPKINSON, D.A., GENETICAL STUDIES ON HUMAN RED CELL ACID PHOSPHATASE, AMERICAN JOURNAL OF HUMAN GENETICS 16: 141 (1964).","journal-title":"AMERICAN JOURNAL OF HUMAN GENETICS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/199969a0","volume":"199","year":"1963","unstructured":"HOPKINSON, D.A., RED CELL ACID PHOSPHATASE VARIANTS - A NEW HUMAN POLYMORPHISM, NATURE 199: 969 (1963).","journal-title":"NATURE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1172\/JCI104206","volume":"39","year":"1960","unstructured":"JANDL, J.H., OXIDATIVE HEMOLYSIS AND PRECIPITATION OF HEMOGLOBIN .1. 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