{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:13:44Z","timestamp":1770632024132,"version":"3.49.0"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3975","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1971,3,12]]},"abstract":"<jats:p>\n            A special proteolipid (a hydrophobic protein) has been extracted and purified from nerve-ending membranes and total particulate matter of gray areas of the central nervous system. Such a proteolipid shows a high affinity for binding\n            <jats:italic>d<\/jats:italic>\n            -tubocurarine, serotonin, and atropine and has been called receptor proteolipid. The interaction of this proteolipid with atropine sulfate was studied with light scattering and polarization of fluorescence. The changes observed, which follow a cooperative type of curve, were attributed to the aggregation of the proteolipid macromolecules. Such a phenomenon was then observed under the electron microscope.\n          <\/jats:p>\n          <jats:p>\n            A receptor proteolipid having a high affinity for binding acetylcholine, hexamethonium, and other cholinergic drugs was isolated and purified from electric tissue of fishes and from electroplax membranes. Such a proteolipid was also extracted from membranes from which acetylcholinesterase had been removed, and it was concluded that this enzyme and the receptor proteolipid are two different macromolecules. A high affinity binding site with a dissociation constant of K\n            <jats:sub>1<\/jats:sub>\n            equal to 10\n            <jats:sup>-7<\/jats:sup>\n            and about ten sites with K\n            <jats:sub>2<\/jats:sub>\n            equal to 10\n            <jats:sup>-5<\/jats:sup>\n            were recognized in the receptor proteolipid.\n          <\/jats:p>\n          <jats:p>\n            Under the electron microscope the receptor proteolipid of brain appears as a rod-shaped macromolecule which may assume paracrystalline arrays with 10\n            <jats:sup>-8<\/jats:sup>\n            molar atropine sulfate. Similarly the receptor proteolipid from electric tissue and from skeletal muscle may form paracrystalline arrays under the action of acetylcholine and hexamethonium.\n          <\/jats:p>\n          <jats:p>A model of the cholinergic receptor based on the properties of the proteolipid is presented. Preliminary work indicates the possibility of obtaining a biophysical response to acetylcholine when the receptor proteolipid is embedded in artificial bilayered lipid membranes.<\/jats:p>","DOI":"10.1126\/science.171.3975.963","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"963-971","source":"Crossref","is-referenced-by-count":153,"title":["Molecular Biology of Synaptic Receptors"],"prefix":"10.1126","volume":"171","author":[{"given":"Eduardo","family":"De Robertis","sequence":"first","affiliation":[{"name":"The Instituto de Anatom\u00eda General y Embriolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"10","volume":"4","year":"1968","unstructured":"ALBUQUERQUE, E.X., EUR J PHARMACOL 4: 10 (1968).","journal-title":"EUR J PHARMACOL"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1113\/jphysiol.1959.sp006233","volume":"147","year":"1959","unstructured":"AXELSSON, J, A STUDY OF SUPERSENSITIVITY IN DENERVATED MAMMALIAN SKELETAL MUSCLE, JOURNAL OF PHYSIOLOGY-LONDON 147: 178 (1959).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0028-3908(67)90038-X","volume":"6","year":"1967","unstructured":"AZCURRA, J.M., INT J NEUROPHARMACOL 6: 15 (1967).","journal-title":"INT J NEUROPHARMACOL"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1749-6632.1961.tb35555.x","volume":"94","year":"1961","unstructured":"BENNETT, MVL, MODES OF OPERATION OF ELECTRIC ORGANS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 94: 458 (1961).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/0006-2952(65)90302-3","volume":"14","year":"1965","unstructured":"BEYCHOK, S, ON PROBLEM OF ISOLATION OF SPECIFIC ACETYLCHOLINE RECEPTOR, BIOCHEMICAL PHARMACOLOGY 14: 1249 (1965).","journal-title":"BIOCHEMICAL PHARMACOLOGY"},{"key":"e_1_2_1_6_1","first-page":"1647","volume":"26","year":"1967","unstructured":"CAVALLITO, C.J., SOME SPECULATIONS ON CHEMICAL NATURE OF POSTJUNCTIONAL MEMBRANE RECEPTORS, FEDERATION PROCEEDINGS 26: 1647 (1967).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0003-9861(58)90414-4","volume":"75","year":"1958","unstructured":"CHAGAS, C, A STUDY OF THE SPECIFICITY OF THE COMPLEX FORMED BY GALLAMINE TRIETHIODIDE WITH A MACROMOLECULAR CONSTITUENT OF THE ELECTRIC ORGAN, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 75: 251 (1958).","journal-title":"ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1085\/jgp.54.1.225","volume":"54","year":"1969","unstructured":"CHANGEUX, J.P., J GEN PHYSIOL 54: 225 (1969).","journal-title":"J GEN PHYSIOL"},{"key":"e_1_2_1_9_1","first-page":"2063","volume":"58","year":"1967","unstructured":"CHANGEUX, J.P., AFFINITY LABELING OF ACETYLCHOLINE-RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 58: 2063 (1967).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_10_1","first-page":"944","volume":"59","year":"1968","unstructured":"CHANGEUX, J.P., ON EXCITABILITY AND COOPERATIVITY OF ELECTROPLAX MEMBRANE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 59: 944 (1968).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.pa.09.040169.001233","volume":"9","year":"1969","unstructured":"CURTIS, D.R., CENTRAL SYNAPTIC TRANSMISSION - 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