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A fraction of the retinol released from rhodopsin during illumination disappears presumably from the pigment epithelium into the blood and becomes unavailable for rhodopsin regeneration. A sequence of three first-order reactions was assumed to estimate the rate constant of this disappearance (0.03 per hour). Computer simulation supporting the experimental data illustrates the dependence of the retinal abnormalities on light.<\/jats:p>","DOI":"10.1126\/science.172.3978.72","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"72-76","source":"Crossref","is-referenced-by-count":94,"title":["Vitamin A Deficiency Effect on Retina: Dependence on Light"],"prefix":"10.1126","volume":"172","author":[{"given":"W. 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