{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:37:22Z","timestamp":1759541842462},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3979","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1971,4,9]]},"abstract":"<jats:p>\n            Aryl hydrocarbon hydroxylase induction by phenobarbital, polycyclic hydrocarbons, and the insecticide, 2.2-bis(p-chlorophenyl)-1,1,1-trichloroethane (\n            <jats:italic>p<\/jats:italic>\n            ,\n            <jats:italic>p<\/jats:italic>\n            \u2032-DDT), occurs in rat fetal liver cell cultures. The maximum net rate at which the hydroxylase activity accumulates is about the same when phenobarbital, 3-methylcholanthrene, or benz[\n            <jats:italic>a<\/jats:italic>\n            ]anthracene is in the growth medium at optimum concentrations. An additive effect is obtained when either phenobarbital or\n            <jats:italic>p<\/jats:italic>\n            ,\n            <jats:italic>p<\/jats:italic>\n            \u2032-DDT is present with a polycyclic hydrocarbon in the growth medium, but not when the cells are treated with phenobarbital plus\n            <jats:italic>p<\/jats:italic>\n            ,\n            <jats:italic>p<\/jats:italic>\n            \u2032-DDT or with the combination of two polycyclic hydrocarbons.\n          <\/jats:p>","DOI":"10.1126\/science.172.3979.167","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"167-169","source":"Crossref","is-referenced-by-count":50,"title":["Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and\n            <i>p<\/i>\n            ,\n            <i>p<\/i>\n            \u2032-DDT"],"prefix":"10.1126","volume":"172","author":[{"given":"J. E.","family":"Gielen","sequence":"first","affiliation":[{"name":"Section on Developmental Enzymology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W.","family":"Nebert","sequence":"additional","affiliation":[{"name":"Section on Developmental Enzymology, Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3784.75"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0003-9861(70)90494-7","volume":"139","year":"1970","unstructured":"BARON, J, FURTHER STUDIES ON RELATIONSHIP OF STIMULATORY EFFECTS OF PHENOBARBITAL AND 3,4-BENZPYRENE ON HEPATIC HEME SYNTHESIS TO THEIR EFFECTS ON HEPATIC MICROSOMAL DRUG OXIDATIONS, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 139: 410 (1970).","journal-title":"ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS"},{"key":"e_1_2_1_3_1","first-page":"493","year":"1967","unstructured":"CAHN, R.D., METHODS DEV BIOL: 493 (1967).","journal-title":"METHODS DEV BIOL"},{"key":"e_1_2_1_4_1","first-page":"317","volume":"19","year":"1967","unstructured":"CONNEY, A.H., PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION, PHARMACOLOGICAL REVIEWS 19: 317 (1967).","journal-title":"PHARMACOLOGICAL REVIEWS"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1016\/S0021-9258(18)61893-9","volume":"246","year":"1971","unstructured":"Gielen, J. 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