{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:05:43Z","timestamp":1762067143995},"reference-count":18,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3990","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1971,6,25]]},"abstract":"<jats:p>\n            Female rats of the poorly responding, inbred F344 strain were immunized with poly(Glu\n            <jats:sup>52<\/jats:sup>\n            Lys\n            <jats:sup>33<\/jats:sup>\n            Tyr\n            <jats:sup>15<\/jats:sup>\n            ) aggregated with methylated bovine serum albumin, and then they were mated. The first and second litters in the F\n            <jats:sub>1<\/jats:sub>\n            generation and in the F\n            <jats:sub>2<\/jats:sub>\n            generation showed an enhanced immune response. When polylysine was used as the aggregating agent, enhancement occurred in only the first litter of the F\n            <jats:sub>1<\/jats:sub>\n            generation and in the F\n            <jats:sub>2<\/jats:sub>\n            generation. In both cases, antigen was transmitted from the immunized female to her offspring, where it localized in the bone marrow and, in a few cases, in the thymus and spleen also. The transplacental passage of antigen is probably the basis for the enhanced antibody response, which is a manifestation of immunological memory.\n          <\/jats:p>","DOI":"10.1126\/science.172.3990.1346","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"1346-1348","source":"Crossref","is-referenced-by-count":23,"title":["Maternal-Fetal Interaction and Immunological Memory"],"prefix":"10.1126","volume":"172","author":[{"suffix":"III","given":"Thomas J.","family":"Gill","sequence":"first","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz W.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colette F.","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/S0021-9258(18)93396-X","volume":"243","year":"1968","unstructured":"J BIOL CHEM 243: 2451 (1968).","journal-title":"J BIOL CHEM"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0065-2776(08)60814-7","volume":"3","year":"1963","unstructured":"CAMPBELL, D.H., NATURE OF RETAINED ANTIGEN AND ITS ROLE IN IMMUNE MECHANISMS, ADVANCES IN IMMUNOLOGY 3: 261 (1963).","journal-title":"ADVANCES IN IMMUNOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0020-708X(56)90020-5","volume":"1","year":"1956","unstructured":"CAMPBELL, R.M., INT J APPL RADIAT IS 1: 66 (1956).","journal-title":"INT J APPL RADIAT IS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4049\/jimmunol.98.2.236","volume":"98","year":"1967","unstructured":"CARPENTER, C.B., SYNTHETIC POLYPEPTIDE METABOLISM .3. 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