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The mutant CFTRs were less sensitive than wild-type CFTR to this activating stimulus, and the reduction in sensitivity correlated with the severity of cystic fibrosis in patients carrying the corresponding mutations. This demonstration provides the basis for detailed analyses of NBF1 function and suggests potential pharmacologic treatments for cystic fibrosis.\n          <\/jats:p>","DOI":"10.1126\/science.1722350","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"1797-1799","source":"Crossref","is-referenced-by-count":383,"title":["Chloride Conductance Expressed by \u0394F508 and Other Mutant CFTRs In\n            <i>Xenopus<\/i>\n            Oocytes"],"prefix":"10.1126","volume":"254","author":[{"given":"Mitchell L.","family":"Drumm","sequence":"first","affiliation":[{"name":"Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Michigan, Ann Arbor, MI 48109."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger T.","family":"Worrell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa V.","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Frizzell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Michigan, Ann Arbor, MI 48109."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis S.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109."},{"name":"Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0092-8674(91)90072-7","volume":"67","year":"1991","unstructured":"ANDERSON, M.P., NUCLEOSIDE TRIPHOSPHATES ARE REQUIRED TO OPEN THE CFTR CHLORIDE CHANNEL, CELL 67: 775 (1991).","journal-title":"CELL"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1704151"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1712984"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014852"},{"key":"e_1_2_1_5_1","first-page":"2649","year":"1989","unstructured":"Boat, T. 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