{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:03:30Z","timestamp":1705017810974},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4006","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1971,10,15]]},"abstract":"<jats:p>\n            Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along with a methylxanthine mimics the effects of illumination on the photoreceptor cell of the compound eye of\n            <jats:italic>Limulus<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1126\/science.174.4006.295","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"295-297","source":"Crossref","is-referenced-by-count":63,"title":["Cyclic Adenosine Monophosphate: Function in Photoreceptors"],"prefix":"10.1126","volume":"174","author":[{"given":"W. H.","family":"Miller","sequence":"first","affiliation":[{"name":"Departments of Ophthalmology and Physiology, Yale Medical School, New Haven, Connecticut 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Gorman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. W.","family":"Bitensky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1085\/jgp.52.4.584","volume":"52","year":"1968","unstructured":"ADOLPH, A.R., THERMAL AND SPECTRAL SENSITIVITIES OF DISCRETE SLOW POTENTIALS IN LIMULUS EYE, JOURNAL OF GENERAL PHYSIOLOGY 52: 584 (1968).","journal-title":"JOURNAL OF GENERAL PHYSIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1085\/jgp.48.6.1081","volume":"48","year":"1965","unstructured":"BEHRENS, M.E., LIGHT-INITIATED RESPONSES OF RETINULA AND ECCENTRIC CELLS IN LIMULUS LATERAL EYE, JOURNAL OF GENERAL PHYSIOLOGY 48: 1081 (1965).","journal-title":"JOURNAL OF GENERAL PHYSIOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/2081282a0","volume":"208","year":"1965","unstructured":"BITENSKY, M.W., EFFECTS OF CYCLIC ADENOSINE MONOPHOSPHATE AND MELANOCYTE-STIMULATING HORMONE ON FRONG SKIN IN VITRO, NATURE 208: 1282 (1965).","journal-title":"NATURE"},{"key":"e_1_2_1_4_1","first-page":"561","volume":"68","year":"1971","unstructured":"BITENSKY, M.W., ADENYL CYCLASE AS A LINK BETWEEN PHOTON CAPTURE AND CHANGES IN MEMBRANE PERMEABILITY OF FROG PHOTORECEPTORS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 561 (1971).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/225870a0","volume":"225","year":"1970","unstructured":"BOWNDS, D, NATURE 225: 870 (1970).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","first-page":"51","year":"1970","unstructured":"CHEUNG, W.Y., ROLE CYCLIC AMP CELL 51 (1970).","journal-title":"ROLE CYCLIC AMP CELL"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.160.3823.88"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/01.RES.25.4.429","volume":"25","year":"1969","unstructured":"ENTMAN, M.L., MECHANISM OF ACTION OF EPINEPHRINE AND GLUCAGON ON CANINE HEART - EVIDENCE FOR INCREASE IN SARCOTUBULAR CALCIUM STORES MEDIATED BY CYCLIC 3',5'-AMP, CIRCULATION RESEARCH 25: 429 (1969).","journal-title":"CIRCULATION RESEARCH"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.164.3877.270"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1085\/jgp.25.6.819","volume":"25","year":"1942","unstructured":"HECHT, S, J GEN PHYSIOL 25: 819 (1942).","journal-title":"J GEN PHYSIOL"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3976.1156"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/223201a0","volume":"223","year":"1969","unstructured":"PENN, R.D., SIGNAL TRANSMISSION ALONG RETINAL RODS AND ORIGIN OF ELECTRORETINOGRAPHIC A-WAVE, NATURE 223: 201 (1969).","journal-title":"NATURE"},{"key":"e_1_2_1_13_1","first-page":"3","volume":"8","year":"1969","unstructured":"RALL, T.W., NEUROSCIENCES RESEARCH PROGRAM BULLETIN 8: 3 (1969).","journal-title":"NEUROSCIENCES RESEARCH PROGRAM BULLETIN"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3956.404"},{"key":"e_1_2_1_15_1","unstructured":"RATLIFF F MACH BANDS QUANTITAT (1965)."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3897.1018"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2337\/diab.18.12.797","volume":"18","year":"1969","unstructured":"SUTHERLAND, E.W., ROLE OF CYCLIC AMP IN CONTROL OF CARBOHYDRATE METABOLISM, DIABETES 18: 797 (1969).","journal-title":"DIABETES"},{"key":"e_1_2_1_18_1","first-page":"3608","volume":"79","year":"1957","unstructured":"Sutherland, E. W., Journal of the American Chemical Society 79: 3608 (1957).","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0033583500004571","volume":"3","year":"1970","unstructured":"TOMITA, T, QUART REV BIOPHYS 3: 179 (1970).","journal-title":"QUART REV BIOPHYS"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1364\/JOSA.53.000020","volume":"53","year":"1963","unstructured":"WALD, G, PROBLEM OF VISUAL EXCITATION, JOURNAL OF THE OPTICAL SOCIETY OF AMERICA 53: 20 (1963).","journal-title":"JOURNAL OF THE OPTICAL SOCIETY OF AMERICA"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.ph.29.030167.002501","volume":"29","year":"1967","unstructured":"WOLBARSCHT, M.L., VISUAL PROCESSES IN LIMULUS EYE, ANNUAL REVIEW OF PHYSIOLOGY 29: 513 (1967).","journal-title":"ANNUAL REVIEW OF PHYSIOLOGY"},{"key":"e_1_2_1_22_1","first-page":"82","volume":"46","year":"1958","unstructured":"YEANDLE, S, AMERICAN JOURNAL OF OPHTHALMOLOGY 46: 82 (1958).","journal-title":"AMERICAN JOURNAL OF OPHTHALMOLOGY"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"A47","DOI":"10.1016\/S0006-3495(71)86194-5","volume":"11","year":"1971","unstructured":"YOSHIKAMI, S, BIOPHYS J 11: A47 (1971).","journal-title":"BIOPHYS J"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.174.4006.295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T16:16:08Z","timestamp":1704989768000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.174.4006.295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,10,15]]},"references-count":23,"journal-issue":{"issue":"4006","published-print":{"date-parts":[[1971,10,15]]}},"alternative-id":["10.1126\/science.174.4006.295"],"URL":"https:\/\/doi.org\/10.1126\/science.174.4006.295","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,10,15]]}}}