{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:14:44Z","timestamp":1758280484500},"reference-count":94,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4018","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1972,1,14]]},"abstract":"<jats:p>Close linkage of mutually exclusive genes occurs in the non-\u03b1 chain hemoglobin genes and in the immunoglobulin genes of man and other mammals. The expression of one gene in the cluster precludes the expression of any other linked gene. A simple, testable theory of gene selection called \"looping-out excision\" which was designed only to explain this mutual exclusivity in the hemoglobin system is described. The theory is closely concordant with a wide range of previously unexplained findings concerning hematopoiesis\u2014including the developmental changes of hemoglobins, the increases in immature or fetal forms of hemoglobin that accompany anemia, and with the distribution of adult and fetal hemoglobins among erythrocytes during normal embryogenesis and in various pathological conditions. One corollary of this theory is that erythroid tissue in the normal adult bone marrow is constantly recapitulating the developmental stages of its embryogenesis. Another corollary is that the selection from among the linked globin genes occurs independently on the two chromosomes of the diploid organism. Both of these corollaries are supported by the available data.<\/jats:p>\n          <jats:p>The same theory of gene selection is also remarkably consistent with known data for immunoglobulin synthesis; it could explain not only the mutually exclusive activation of linked variable genes but also the splicing which occurs between genetically linked variable and constant region genes for the immunoglobulin polypeptide chains. The agreement between these two different tissues is considered to be strong evidence that the proposed mechanism is correct at least in broad outline. Evidence from the genetics of maize and of drosophila also supports this theory of somatic tissue variegation. On the basis of these comparisons, I suggest that looping-out excision probably occurs also in other tissues and may be one means of gene selection and activation in differentiating cells.<\/jats:p>","DOI":"10.1126\/science.175.4018.134","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"134-140","source":"Crossref","is-referenced-by-count":42,"title":["Gene Selection in Hemoglobin and in Antibody-Synthesizing Cells"],"prefix":"10.1126","volume":"175","author":[{"given":"David","family":"Kabat","sequence":"first","affiliation":[{"name":"University of Oregon Medical School, Portland 97201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0022-2836(68)90396-3","volume":"38","year":"1968","unstructured":"ARDITTI, R.R., NATURE OF MUTANTS IN LAC PROMOTER REGION, JOURNAL OF MOLECULAR BIOLOGY 38: 421 (1968).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_2_1","first-page":"405","volume":"1","year":"1963","unstructured":"Baglioni, C., Molecular Genetics 1: 405 (1963).","journal-title":"Molecular Genetics"},{"key":"e_1_2_1_3_1","first-page":"1880","volume":"48","year":"1962","unstructured":"BAGLIONI, C, FUSION OF 2 PEPTIDE CHAINS IN HEMOGLOBIN LEPORE AND ITS INTERPRETATION AS A GENETIC DELETION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 48: 1880 (1962).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/194931a0","volume":"194","year":"1962","unstructured":"BARNABAS, J, NATURE 194: 931 (1962).","journal-title":"NATURE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/2091099a0","volume":"209","year":"1966","unstructured":"BEALE, D, HAEMOGLOBINS OF SHEEP, NATURE 209: 1099 (1966).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/197452a0","volume":"197","year":"1963","unstructured":"BECKER, A.J., CYTOLOGICAL DEMONSTRATION OF CLONAL NATURE OF SPLEEN COLONIES DERIVED FROM TRANSPLANTED MOUSE MARROW CELLS, NATURE 197: 452 (1963).","journal-title":"NATURE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1172\/JCI105763","volume":"47","year":"1968","unstructured":"BERTLES, J.F., DISPROPORTIONAL SYNTHESIS OF ADULT DUCKS 2 HEMOGLOBINS DURING ACUTE ANEMIA, JOURNAL OF CLINICAL INVESTIGATION 47: 679 (1968).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_8_1","first-page":"731","year":"1970","unstructured":"Bertles, J. F., Regulation of Hematopolesis: 731 (1970).","journal-title":"Regulation of Hematopolesis"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF01630321","volume":"4","year":"1958","unstructured":"BETKE, K, BLUT 4: 241 (1958).","journal-title":"BLUT"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/00007890-196511000-00002","volume":"3","year":"1965","unstructured":"BLEIBERG, I, TRANSPLANTATION 3: 706 (1965).","journal-title":"TRANSPLANTATION"},{"key":"e_1_2_1_11_1","first-page":"438","volume":"15","year":"1963","unstructured":"BOYER, S.H., FURTHER EVIDENCE FOR LINKAGE BETWEEN BETA AND DELTA LOCI GOVERNING HUMAN HEMOGLOBIN AND POPULATION DYNAMICS OF LINKED GENES, AMERICAN JOURNAL OF HUMAN GENETICS 15: 438 (1963).","journal-title":"AMERICAN JOURNAL OF HUMAN GENETICS"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/S0021-9258(18)96038-2","volume":"242","year":"1967","unstructured":"BOYER, S.H., DIFFERENCES IN AMINO ACID SEQUENCES OF TRYPTIC PEPTIDES FROM 3 SHEEP HEMOGLOBIN BETA CHAINS, JOURNAL OF BIOLOGICAL CHEMISTRY 242: 2211 (1967).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/oxfordjournals.jhered.a107614","volume":"58","year":"1967","unstructured":"BOYER, S, QUANTITATIVE DISPARITY BETWEEN HEMOGLOBINS - NATURAL MODELS FOR ANALYSIS OF CONTROL OF PROTEIN BIOSYNTHESIS, JOURNAL OF HEREDITY 58: 279 (1967).","journal-title":"JOURNAL OF HEREDITY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3743.1539"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/genetics\/39.5.724","volume":"39","year":"1954","unstructured":"BRINK, R.A., VERY LIGHT VARIEGATED PERICARP IN MAIZE, GENETICS 39: 724 (1954).","journal-title":"GENETICS"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/jcp.1030520410","volume":"52","year":"1958","unstructured":"BRINK, R.A., J CELL COMP PHYSL 52: 169 (1958).","journal-title":"J CELL COMP PHYSL"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.159.3811.161"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1182\/blood.V23.2.216.216","volume":"23","year":"1964","unstructured":"BRUCE, W.R., EFFECT OF ERYTHROPOIETIC STIMULATION ON HEMOPOIETIC COLONY-FORMING CELLS OF MICE, BLOOD 23: 216 (1964).","journal-title":"BLOOD"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.mi.24.100170.001325","volume":"24","year":"1970","unstructured":"CALENDAR, R, REGULATION OF PHAGE DEVELOPMENT, ANNUAL REVIEW OF MICROBIOLOGY 24: 241 (1970).","journal-title":"ANNUAL REVIEW OF MICROBIOLOGY"},{"key":"e_1_2_1_20_1","first-page":"101","volume":"11","year":"1962","unstructured":"CAMPBELL, A, EPISOMES, ADVANCES IN GENETICS INCORPORATING MOLECULAR GENETIC MEDICINE 11: 101 (1962).","journal-title":"ADVANCES IN GENETICS INCORPORATING MOLECULAR GENETIC MEDICINE"},{"key":"e_1_2_1_21_1","first-page":"278","volume":"228","year":"1970","unstructured":"CAPP, G.L., EVIDENCE FOR A NEW HAEMOGLOBIN CHAIN (ZETA-CHAIN), NATURE 228: 278 (1970).","journal-title":"NATURE"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1084\/jem.123.3.547","volume":"123","year":"1966","unstructured":"CEBRA, J.J., RABBIT LYMPHOID CELLS DIFFERENTIATED WITH RESPECT TO ALPHA- GAMMA- AND MU- HEAVY POLYPEPTIDE CHAINS AND TO ALLOTYPIC MARKERS AA1 AND AA2, JOURNAL OF EXPERIMENTAL MEDICINE 123: 547 (1966).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4049\/jimmunol.104.4.976","volume":"104","year":"1970","unstructured":"COSENZA, H, IMMUNOGLOBULIN CLASSES OF ANTIBODY-FORMING CELLS IN MICE .3. IMMUNOGLOBULIN ANTIBODY RESTRICTION OF PLAQUE-FORMING CELLS DEMONSTRATED BY DOUBLE IMMUNOFLUORESCENT TECHNIQUE, JOURNAL OF IMMUNOLOGY 104: 976 (1970).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0012-1606(67)90034-6","volume":"15","year":"1967","unstructured":"CURRY, J.L., HEMOPOIETIC SPLEEN COLONY STUDIES .I. GROWTH AND DIFFERENTIATION, DEVELOPMENTAL BIOLOGY 15: 395 (1967).","journal-title":"DEVELOPMENTAL BIOLOGY"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.125.4.703","volume":"125","year":"1967","unstructured":"CURRY, J.L., HEMOPOIETIC SPLEEN COLONY STUDIES .2. ERYTHROPOIESIS, JOURNAL OF EXPERIMENTAL MEDICINE 125: 703 (1967).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0014-4827(67)90385-0","volume":"46","year":"1967","unstructured":"DAN, M, DETECTION OF 2 TYPES OF HEMOGLOBIN (HBA AND HBF) IN SINGLE ERYTHROCYTES BY FLUORESCENT ANTIBODY TECHNIQUE, EXPERIMENTAL CELL RESEARCH 46: 596 (1967).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/hdy.1963.1","volume":"18","year":"1963","unstructured":"DAWSON, GWP, HEREDITY 18: 1 (1963).","journal-title":"HEREDITY"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jcp.1030620408","volume":"62","year":"1963","unstructured":"DAWSON, GWP, J CELL COMP PHYSI S1 62: 73 (1963).","journal-title":"J CELL COMP PHYSI S1"},{"key":"e_1_2_1_29_1","unstructured":"Dayhoff M. O. Atlas of Protein Sequence and Structure 4 (1969)."},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1101\/SQB.1941.009.01.018","volume":"9","year":"1941","unstructured":"Demerec, M., Cold Spring Harbor Symposia on Quantitative Biology 9: 145 (1941).","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1749-6632.1968.tb15159.x","volume":"149","year":"1968","unstructured":"DORNFEST, B.S., EFFECT OF ERYTHROPOIETIN ON RETICULOCYTE RELEASE FROM ISOLATED PERFUSED RAT SPLEEN, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 149: 249 (1968).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_32_1","first-page":"864","volume":"54","year":"1965","unstructured":"DREYER, W.J., MOLECULAR BASIS OF ANTIBODY FORMATION - A PARADOX, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 54: 864 (1965).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0022-2836(70)90324-4","volume":"47","year":"1970","unstructured":"ECHOLS, H, J MOL BIOL 47: 575 (1970).","journal-title":"J MOL BIOL"},{"key":"e_1_2_1_34_1","first-page":"342","volume":"68","year":"1971","unstructured":"FOX, A.S., DNA-INDUCED TRANSFORMATION IN DROSOPHILA - GENETIC ANALYSIS OF TRANSFORMED STOCKS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 342 (1971).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_35_1","first-page":"1608","volume":"67","year":"1970","unstructured":"FOX, A.S., DNA-INDUCED TRANSFORMATION IN DROSOPHILA - LOCUS-SPECIFICITY AND ESTABLISHMENT OF TRANSFORMED STOCKS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67: 1608 (1970).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_36_1","first-page":"1834","volume":"67","year":"1970","unstructured":"FOX, A.S., DNA-INDUCED TRANSFORMATION IN DROSOPHILA - EVIDENCE FOR TRANSMISSION WITHOUT INTEGRATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67: 1834 (1970).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/adc.37.193.289","volume":"37","year":"1962","unstructured":"FRASER, I.D., OBSERVATIONS ON CHANGE FROM FOETAL TO ADULT ERYTHROPOIESIS, ARCHIVES OF DISEASE IN CHILDHOOD 37: 289 (1962).","journal-title":"ARCHIVES OF DISEASE IN CHILDHOOD"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0014-4827(64)90227-7","volume":"36","year":"1964","unstructured":"FRASER, R.C., SIMILARITY OF HEMOGLOBINS IN 2 CELL POPULATIONS IN CHICK EMBRYO, EXPERIMENTAL CELL RESEARCH 36: 429 (1964).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_39_1","first-page":"200","volume":"65","year":"1970","unstructured":"FREIFELDER, D, TOPOLOGICAL RELATIONSHIP OF PROPHAGE LAMBDA TO BACTERIAL CHROMOSOME IN LYSOGENIC CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 65: 200 (1970).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1749-6632.1969.tb27804.x","volume":"165","year":"1969","unstructured":"GABUZDA, T.G., CONTROL OF HEMOGLOBIN PHENOTYPE IN CALVES AND SHEEP, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 165: 347 (1969).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_41_1","first-page":"111","volume":"1","year":"1970","unstructured":"Gordon, A. J., Regulation of Hematopoiesis 1: 111 (1970).","journal-title":"Regulation of Hematopoiesis"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/genetics\/47.4.489","volume":"47","year":"1962","unstructured":"GREENBLATT, I.M., TWIN MUTATIONS IN MEDIUM VARIEGATED PERICARP MAIZE, GENETICS 47: 489 (1962).","journal-title":"GENETICS"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0022-2836(70)90323-2","volume":"47","year":"1970","unstructured":"GUARNEROS, G, J MOL BIOL 47: 565 (1970).","journal-title":"J MOL BIOL"},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/217569a0","volume":"217","year":"1968","unstructured":"HALL, J.G., PRODUCTION OF FOETAL HAEMOGLOBIN IN MARROW CULTURES OF HUMAN ADULTS, NATURE 217: 569 (1968).","journal-title":"NATURE"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3718.91"},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1749-6632.1969.tb27776.x","volume":"165","year":"1969","unstructured":"HELLER, P, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 165: 54 (1969).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_47_1","unstructured":"Hilschman N. Plenary Sessions Scientific Contributions 13th Intemational Congress of Hematology (1970)."},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3929.325"},{"key":"e_1_2_1_49_1","first-page":"394","volume":"15","year":"1963","unstructured":"HORTON, B.F., LINKAGE OF BETA-CHAIN AND DELTA-CHAIN STRUCTURAL GENES OF HUMAN HEMOGLOBINS, AMERICAN JOURNAL OF HUMAN GENETICS 15: 394 (1963).","journal-title":"AMERICAN JOURNAL OF HUMAN GENETICS"},{"key":"e_1_2_1_50_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0009-8981(61)90091-2","volume":"6","year":"1961","unstructured":"HORTON, B, CLINICA CHIMICA ACTA 6: 246 (1961).","journal-title":"CLINICA CHIMICA ACTA"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1749-6632.1968.tb15176.x","volume":"149","year":"1968","unstructured":"HRINDA, M.E., STUDIES ON CONTROL OF HEMOGLOBIN FORMATION IN MARROW CELLS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 149: 412 (1968).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_52_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/189496a0","volume":"189","year":"1961","unstructured":"HUEHNS, E.R., 2 NEW HAEMOGLOBIN VARIANTS IN A VERY YOUNG HUMAN EMBRYO, NATURE 189: 496 (1961).","journal-title":"NATURE"},{"key":"e_1_2_1_53_1","first-page":"505","volume":"22","year":"1970","unstructured":"HUISMAN, T. H. J., AM J HUM GENET 22: 505 (1970).","journal-title":"AM J HUM GENET"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1749-6632.1969.tb27802.x","volume":"165","year":"1969","unstructured":"HUISMAN, T. H. J., EVIDENCE FOR MULTIPLE STRUCTURAL GENES FOR GAMMA-CHAIN OF HUMAN FETAL HEMOGLOBIN IN HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 165: 320 (1969).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_55_1","first-page":"471","volume":"1","year":"1970","unstructured":"Huisman, T. H. J., CRC Crtical Reviews In Clinical Laboratory 1: 471 (1970).","journal-title":"CRC Crtical Reviews In Clinical Laboratory"},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1203\/00006450-196905000-00001","volume":"3","year":"1969","unstructured":"HUISMAN, T. H. J., HEMOGLOBIN C IN NEWBORN SHEEP AND GOATS - A POSSIBLE EXPLANATION FOR ITS FUNCTION AND BIOSYNTHESIS, PEDIATRIC RESEARCH 3: 189 (1969).","journal-title":"PEDIATRIC RESEARCH"},{"key":"e_1_2_1_57_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/217825a0","volume":"217","year":"1968","unstructured":"IPPEN, K, NEW CONTROLLING ELEMENT IN LAC OPERON OF E COLI, NATURE 217: 825 (1968).","journal-title":"NATURE"},{"key":"e_1_2_1_58_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1101\/SQB.1961.026.01.024","volume":"26","year":"1961","unstructured":"JACOB, F, ON REGULATION OF GENE ACTIVITY, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 26: 193 (1961).","journal-title":"COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"},{"key":"e_1_2_1_59_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0022-2836(61)80072-7","volume":"3","year":"1961","unstructured":"JACOB, F, GENETIC REGULATORY MECHANISMS IN SYNTHESIS OF PROTEINS, JOURNAL OF MOLECULAR BIOLOGY 3: 318 (1961).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_60_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0022-2836(70)90322-0","volume":"47","year":"1970","unstructured":"KAISER, A.D., J MOL BIOL 47: 557 (1970).","journal-title":"J MOL BIOL"},{"key":"e_1_2_1_61_1","first-page":"1918","volume":"67","year":"1970","unstructured":"KINCADE, P.W., SUPPRESSION OF IMMUNOGLOBULIN-G SYNTHESIS AS A RESULT OF ANTIBODY-MEDIATED SUPPRESSION OF IMMUNOGLOBULIN M SYNTHESIS IN CHICKENS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67: 1918 (1970).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_62_1","first-page":"281","volume":"29","year":"1968","unstructured":"KITCHEN, H, RAPID PRODUCTION OF A HEMOGLOBIN BY INDUCED HEMOLYSIS IN SHEEP - HEMOGLOBIN C, AMERICAN JOURNAL OF VETERINARY RESEARCH 29: 281 (1968).","journal-title":"AMERICAN JOURNAL OF VETERINARY RESEARCH"},{"key":"e_1_2_1_63_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/BF01481043","volume":"35","year":"1957","unstructured":"KLEIHAUER, E, DEMONSTRATION VON FETALEM HAMOGLOBIN IN DEN ERYTHROCYTEN EINES BLUTAUSSTRICHS, KLINISCHE WOCHENSCHRIFT 35: 637 (1957).","journal-title":"KLINISCHE WOCHENSCHRIFT"},{"key":"e_1_2_1_64_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1749-6632.1968.tb15178.x","volume":"149","year":"1968","unstructured":"KRAUS, L.M., EFFECT OF ERYTHROPOIETIN UPON HEMOGLOBIN BIOSYNTHESIS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 149: 423 (1968).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_65_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.bi.36.070167.002053","volume":"36","year":"1967","unstructured":"LENNOX, E.S., IMMUNOGLOBULINS, ANNUAL REVIEW OF BIOCHEMISTRY 36: 365 (1967).","journal-title":"ANNUAL REVIEW OF BIOCHEMISTRY"},{"key":"e_1_2_1_66_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/204589a0","volume":"204","year":"1964","unstructured":"LEWIS, J.P., HAEMATOPOIETIC STEM CELLS, NATURE 204: 589 (1964).","journal-title":"NATURE"},{"key":"e_1_2_1_67_1","first-page":"860","volume":"61","year":"1968","unstructured":"MARCHALONIS, J.J., ELECTROPHORETIC ANALYSIS OF ANTIBODY PRODUCED BY SINGLE CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 61: 860 (1968).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3705.1824"},{"key":"e_1_2_1_69_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1101\/SQB.1956.021.01.017","volume":"21","year":"1956","unstructured":"MCCLINTOCK, B, CONTROLLING ELEMENTS AND THE GENE, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 21: 197 (1956).","journal-title":"COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"},{"key":"e_1_2_1_70_1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/2201287a0","volume":"220","year":"1968","unstructured":"MILLER, J.H., DIRECTION OF TRANSCRIPTON OF A REGULATORY GENE IN E COLI, NATURE 220: 1287 (1968).","journal-title":"NATURE"},{"key":"e_1_2_1_71_1","first-page":"53","volume":"23","year":"1966","unstructured":"MILLER, O.L., NATIONAL CANCER INSTITUTE MONOGRAPHS 23: 53 (1966).","journal-title":"NATIONAL CANCER INSTITUTE MONOGRAPHS"},{"key":"e_1_2_1_72_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.mi.24.100170.002003","volume":"24","year":"1970","unstructured":"MILSTEIN, C, GENETIC BASIS OF ANTIBODY SPECIFICITY, ANNUAL REVIEW OF MICROBIOLOGY 24: 335 (1970).","journal-title":"ANNUAL REVIEW OF MICROBIOLOGY"},{"key":"e_1_2_1_73_1","first-page":"314","volume":"28","year":"1966","unstructured":"MOORE, S. L., BLOOD-THE JOURNAL OF HEMATOLOGY 28: 314 (1966).","journal-title":"BLOOD-THE JOURNAL OF HEMATOLOGY"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.141.3576.123"},{"key":"e_1_2_1_75_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.mi.16.100162.000413","volume":"16","year":"1962","unstructured":"NOSSAL, GJV, ELABORATION OF ANTIBODIES BY SINGLE CELLS, ANNUAL REVIEW OF MICROBIOLOGY 16: 53 (1962).","journal-title":"ANNUAL REVIEW OF MICROBIOLOGY"},{"key":"e_1_2_1_76_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1749-6632.1968.tb15153.x","volume":"149","year":"1968","unstructured":"ORLIC, D, ULTRASTRUCTURAL AND AUTORADIOGRAPHIC STUDIES OERYTHROPOIETIN-INDUCED RED CELL PRODUCTION, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 149: 198 (1968).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_77_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1084\/jem.122.5.853","volume":"122","year":"1965","unstructured":"PERNIS, B, CELLULAR LOCALIZATION OF IMMUNOGLOBULINS WITH DIFFERENT ALLOTYPIC SPECIFICITIES IN RABBIT LYMPHOID TISSUES, JOURNAL OF EXPERIMENTAL MEDICINE 122: 853 (1965).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_78_1","first-page":"287","volume":"21","year":"1964","unstructured":"RAPER, A.B., JOURNAL OF MEDICAL LABORATORY TECHNOLOGY 21: 287 (1964).","journal-title":"JOURNAL OF MEDICAL LABORATORY TECHNOLOGY"},{"key":"e_1_2_1_79_1","first-page":"449","volume":"23","year":"1966","unstructured":"RITOSSA, F.M., NATIONAL CANCER INSTITUTE MONOGRAPHS 23: 449 (1966).","journal-title":"NATIONAL CANCER INSTITUTE MONOGRAPHS"},{"key":"e_1_2_1_80_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/SQB.1966.031.01.052","volume":"31","year":"1966","unstructured":"SCAIFE, J, MUTATIONAL ALTERATION OF MAXIMAL LEVEL OF LAC OPERON EXPRESSION, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 31: 403 (1966).","journal-title":"COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"},{"key":"e_1_2_1_81_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1749-6632.1968.tb15161.x","volume":"149","year":"1968","unstructured":"SCHOOLEY, J. C., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 149: 266 (1968).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_82_1","first-page":"537","volume":"60","year":"1968","unstructured":"SCHROEDER, W.A., EVIDENCE FOR MULTIPLE STRUCTURAL GENES FOR GAMMA CHAIN OF HUMAN FETAL HEMOGLOBIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 60: 537 (1968).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_83_1","first-page":"26","year":"1970","unstructured":"Schroeder, W. A., Plenary Sessions Scientific Contributions, 13th International Congress of Hematology: 26 (1970).","journal-title":"Plenary Sessions Scientific Contributions, 13th International Congress of Hematology"},{"key":"e_1_2_1_84_1","first-page":"392","volume":"3","year":"1968","unstructured":"Serra, J. A., Modem Genetics 3: 392 (1968).","journal-title":"Modem Genetics"},{"key":"e_1_2_1_85_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM196201182660303","volume":"266","year":"1962","unstructured":"SHAHIDI, N.T., ALKALI-RESISTANT HEMOGLOBIN IN APLASTIC ANEMIA OF BOTH ACQUIRED AND CONGENITAL TYPES, NEW ENGLAND JOURNAL OF MEDICINE 266: 117 (1962).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_86_1","first-page":"293","volume":"110","year":"1962","unstructured":"SHEPARD, M.K., SEMI-QUANTITATIVE ESTIMATION OF DISTRIBUTION OF FETAL HEMOGLOBIN IN RED CELL POPULATIONS, BULLETIN OF THE JOHNS HOPKINS HOSPITAL 110: 293 (1962).","journal-title":"BULLETIN OF THE JOHNS HOPKINS HOSPITAL"},{"key":"e_1_2_1_87_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.mi.22.100168.002315","volume":"22","year":"1968","unstructured":"SIGNER, E.R., LYSOGENY - INTEGRATION PROBLEM, ANNUAL REVIEW OF MICROBIOLOGY 22: 451 (1968).","journal-title":"ANNUAL REVIEW OF MICROBIOLOGY"},{"key":"e_1_2_1_88_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/196232a0","volume":"196","year":"1962","unstructured":"SMITHIES, O, CHROMOSOMAL REARRANGEMENTS AND EVOLUTION OF HAPTOGLOBIN GENES, NATURE 196: 232 (1962).","journal-title":"NATURE"},{"key":"e_1_2_1_89_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1749-6632.1968.tb15149.x","volume":"149","year":"1968","unstructured":"STOHLMAN, F, REGULATION OF ERYTHROPOIESIS .20. KINETICS OF RED CELL PRODUCTION, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 149: 156 (1968).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_90_1","first-page":"29","volume":"51","year":"1964","unstructured":"TILL, J.E., STOCHASTIC MODEL OF STEM CELL PROLIFERATION BASED ON GROWTH OF SPLEEN COLONY-FORMING CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 51: 29 (1964).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_91_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/bj0930401","volume":"93","year":"1964","unstructured":"VANVLIET, G, CHANGES IN HAEMOGLOBIN TYPES OF SHEEP AS RESPONSE TO ANAEMIA, BIOCHEMICAL JOURNAL 93: 401 (1964).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_92_1","unstructured":"Weatherall D. J. The Thalassemia Syndromes (1965)."},{"key":"e_1_2_1_93_1","unstructured":"Wintrobe M. M. Clinical Hematology 6 (1967)."},{"key":"e_1_2_1_94_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1182\/blood.V24.2.198.198","volume":"24","year":"1964","unstructured":"YAKULIS, V.J., ELUTION TEST FOR VISUALIZATION OF HEMOGLOBIN S IN BLOOD SMEARS, BLOOD 24: 198 (1964).","journal-title":"BLOOD"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.175.4018.134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:57:14Z","timestamp":1704985034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.175.4018.134"}},"subtitle":["A process of intrachromosomal crossing-over selects and activates genes in two different tissues."],"short-title":[],"issued":{"date-parts":[[1972,1,14]]},"references-count":94,"journal-issue":{"issue":"4018","published-print":{"date-parts":[[1972,1,14]]}},"alternative-id":["10.1126\/science.175.4018.134"],"URL":"https:\/\/doi.org\/10.1126\/science.175.4018.134","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,1,14]]}}}