{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:50:18Z","timestamp":1757541018160},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4022","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1972,2,11]]},"abstract":"<jats:p>\n            The relation of cellular sex genotype to phenotype was examined in seminal vesicles of adult allophenic mice with cellular sex chromosome mosaicism. Each animal originated from conjoined blastomeres of an embryo of female (XX) and one of male (XY) constitution, from different inbred strains. Cells of both sexes were detected in bone marrow and certain other somatic tissues; cellular sex of seminal vesicles was deduced from strain-associated electrophoretic variants of proteins coded for at autosomal loci. Seminal vesicles composed partly or entirely of female cells were found in male and pseudohermaphrodite individuals. In a pseudohermaphrodite, both allelic variants of the tissue-specific normal male seminal vesicle protein (\n            <jats:italic>Svp<\/jats:italic>\n            -locus) were present, signifying that female as well as male cells were synthesizing the protein. Male-determining factors on the Y chromosome are thus not required in cells that differentiate into functional seminal vesicles.\n          <\/jats:p>","DOI":"10.1126\/science.175.4022.657","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"657-659","source":"Crossref","is-referenced-by-count":4,"title":["Seminal Vesicle Formation and Specific Male Protein Secretion by Female Cells in Allophenic Mice"],"prefix":"10.1126","volume":"175","author":[{"given":"Beatrice","family":"Mintz","sequence":"first","affiliation":[{"name":"Institute for Cancer Research, Philadelphia, Pennsylvania 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Domon","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Philadelphia, Pennsylvania 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Hungerford","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Philadelphia, Pennsylvania 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Morrow","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Philadelphia, Pennsylvania 19111"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF01458495","volume":"2","year":"1969","unstructured":"BAKER, W.W., SUBUNIT STRUCTURE AND GENE CONTROL OF MOUSE NADP-MALATE DEHYDROGENASE, BIOCHEMICAL GENETICS 2: 351 (1969).","journal-title":"BIOCHEMICAL GENETICS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1210\/endo-84-2-435","volume":"84","year":"1969","unstructured":"BARDIN, C.W., SECRETION OF TESTOSTERONE BY PSEUDOHERMAPHRODITE RAT, ENDOCRINOLOGY 84: 435 (1969).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_3_1","first-page":"2032","volume":"68","year":"1971","unstructured":"CONDAMINE, H, GENE CONTROLE OF NEOPLASIA .2. 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S., JOURNAL OF EXPERIMENTAL ZOOLOGY 158: 263 (1965).","journal-title":"JOURNAL OF EXPERIMENTAL ZOOLOGY"},{"key":"e_1_2_1_8_1","first-page":"432","volume":"2","year":"1962","unstructured":"MINTZ, B, AMERICAN ZOOLOGIST 2: 432 (1962).","journal-title":"AMERICAN ZOOLOGIST"},{"key":"e_1_2_1_9_1","first-page":"11","volume":"5","year":"1969","unstructured":"MINTZ, B, BIRTH DEFECTS-ORIGINAL ARTICLE SERIES 5: 11 (1969).","journal-title":"BIRTH DEFECTS-ORIGINAL ARTICLE SERIES"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/genetics\/61.1.41","volume":"61","year":"1969","unstructured":"MINTZ, B, GENETICS 61 Supplement: 41 (1969).","journal-title":"GENETICS"},{"key":"e_1_2_1_11_1","first-page":"43","volume":"64","year":"1970","unstructured":"MINTZ, B, GENETICS 64 Supplement: 43 (1970).","journal-title":"GENETICS"},{"key":"e_1_2_1_12_1","unstructured":"Mintz B. in preparation."},{"key":"e_1_2_1_13_1","first-page":"51","volume":"27","year":"1968","unstructured":"MINTZ, B, JOURNAL OF ANIMAL SCIENCE 27 1: 51 (1968).","journal-title":"JOURNAL OF ANIMAL SCIENCE"},{"key":"e_1_2_1_14_1","first-page":"186","year":"1971","unstructured":"Mintz, B., Methods in Mammalian Embryology: 186 (1971).","journal-title":"Methods in Mammalian Embryology"},{"key":"e_1_2_1_15_1","first-page":"344","volume":"58","year":"1967","unstructured":"MINTZ, B, GENE CONTROL OF MAMMALIAN PIGMENTARY DIFFERENTIATION .I. 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