{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:09:24Z","timestamp":1774321764252,"version":"3.50.1"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4037","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1972,5,26]]},"abstract":"<jats:p>The cerebral and cerebellar cortices of man are richly provided with varicose noradrenaline nerve terminals, which are visualized by fluorescence histochemistry of brain smears obtained by a new technique. The density of such nerves in human cortices equals that of the rat. The method permits simple and rapid analysis of noradrenergic nerves of the human cortex during routine neurosurgical operations.<\/jats:p>","DOI":"10.1126\/science.176.4037.924","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"924-926","source":"Crossref","is-referenced-by-count":38,"title":["Noradrenaline Nerve Terminals in Human Cerebral Cortices: First Histochemical Evidence"],"prefix":"10.1126","volume":"176","author":[{"given":"Bo","family":"Nystr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Akademiska Sjukhuset, 750 14 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Histology, Karolinska Institutet, 104 01 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urban","family":"Ungerstedt","sequence":"additional","affiliation":[{"name":"Department of Histology, Karolinska Institutet, 104 01 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1748-1716.1966.tb03318.x","volume":"67","year":"1966","unstructured":"ANDEN, N.E., ASCENDING MONOAMINE NEURONS TO TELENCEPHALON AND DIENCEPHALON, ACTA PHYSIOLOGICA SCANDINAVICA 67: 313 (1966).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.1962.tb02477.x","volume":"56","year":"1962","unstructured":"CARLSSON, A, ACTA PHYSIOLOGICA SCANDINAVICA 56 196: 1 (1962).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(71)90413-6","volume":"29","year":"1971","unstructured":"CORRODI, H, MINOR TRANQUILLIZERS, STRESS AND CENTRAL CATECHOLAMINE NEURONS, BRAIN RESEARCH 29: 1 (1971).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-2999(70)90059-2","volume":"12","year":"1970","unstructured":"CORRODI, H, STUDIES ON CENTRAL AND PERIPHERAL NORADRENALINE NEURONS USING A NEW DOPAMINE-BETA-HYDROXYLASE INHIBITOR, EUROPEAN JOURNAL OF PHARMACOLOGY 12: 145 (1970).","journal-title":"EUROPEAN JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/15.2.65","volume":"15","year":"1967","unstructured":"CORRODI, H, FORMALDEHYDE FLUORESCENCE METHOD FOR HISTOCHEMICAL DEMONSTRATION OF BIOGENIC MONOAMINES - A REVIEW ON METHODOLOGY, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 15: 65 (1967).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_6_1","first-page":"1","volume":"62","year":"1964","unstructured":"DAHLSTROM, A, ACTA PHYSIOLOGICA SCANDINAVICA 62 232: 1 (1964).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.1965.tb04148.x","volume":"64","year":"1965","unstructured":"DAHLSTROM, A, ACTA PHYSIOLOGICA SCANDINAVICA 64 247: 1 (1965).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/10.3.348","volume":"10","year":"1962","unstructured":"FALCK, B, FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 10: 348 (1962).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_9_1","first-page":"37","volume":"64","year":"1965","unstructured":"FUXE, K, ACTA PHYSIOLOGICA SCANDINAVICA 64: 37 (1965).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-8993(68)90175-3","volume":"8","year":"1968","unstructured":"FUXE, K, BRAIN RES 8: 125 (1968).","journal-title":"BRAIN RES"},{"key":"e_1_2_1_11_1","first-page":"627","volume":"1","year":"1970","unstructured":"FUXE, K, RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 1: 627 (1970).","journal-title":"RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF00337069","volume":"65","year":"1965","unstructured":"FUXE, K, ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE 65: 573 (1965).","journal-title":"ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE"},{"key":"e_1_2_1_13_1","first-page":"1","year":"1967","unstructured":"HAMBERGER, B, ACTA PHYSIOLOGICA SCANDINAVICA 295 1 (1967).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_14_1","first-page":"63","volume":"9","year":"1969","unstructured":"HOKFELT, T, CEREBELLAR MONOAMINE NERVE TERMINALS, A NEW TYPE OF AFFERENT FIBERS TO CORTEX CEREBELLI, EXPERIMENTAL BRAIN RESEARCH 9: 63 (1969).","journal-title":"EXPERIMENTAL BRAIN RESEARCH"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/17.11.714","volume":"17","year":"1969","unstructured":"JONSSON, G, MICROFLUORIMETRIC STUDIES ON FORMALDEHYDE-INDUCED FLUORESCENCE OF NORADRENALINE IN ADRENERGIC NERVES OF RAT IRIS, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 17: 714 (1969).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/19.12.747","volume":"19","year":"1971","unstructured":"LIDBRINK, P, SEMIQUANTITATIVE ESTIMATION OF FORMALDEHYDE-INDICED FLUORESCENCE OF NORADRENALINE IN CENTRAL NORADRENALINE NERVE TERMINALS, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 19: 747 (1971).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0006-8993(70)90089-2","volume":"17","year":"1970","unstructured":"OLSON, L, MONOAMINE FLUORESCENCE IN CNS SMEARS . SENSITIVE AND RAPID VISUALIZATION OF NERVE TERMINALS WITHOUT FREEZE-DRYING, BRAIN RESEARCH 17: 343 (1970).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0006-8993(71)90533-6","volume":"28","year":"1971","unstructured":"OLSON, L, PROJECTIONS FROM LOCUS COERULEUS NORADRENALINE NEURONS - CEREBELLAR INNERVATION, BRAIN RESEARCH 28: 165 (1971).","journal-title":"BRAIN RESEARCH"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF00304572","volume":"15","year":"1968","unstructured":"OLSON, L, COMBINED FLUORESCENCE HISTOCHEMISTRY AND 3H-NORADRENALINE MEASUREMENTS OF ADRENERGIC NERVES, HISTOCHEMIE 15: 38 (1968).","journal-title":"HISTOCHEMIE"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF00310544","volume":"22","year":"1970","unstructured":"OLSON, L, A SIMPLE HIGH CAPACITY FREEZE-DRIER FOR HISTOCHEMICAL USE, HISTOCHEMIE 22: 8 (1970).","journal-title":"HISTOCHEMIE"},{"key":"e_1_2_1_21_1","first-page":"1","year":"1971","unstructured":"UNGERSTEDT, U, ACTA PHYSIOLOGICA SCANDINAVICA: 1 (1971).","journal-title":"ACTA PHYSIOLOGICA SCANDINAVICA"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.176.4037.924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T15:47:24Z","timestamp":1704988044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.176.4037.924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5,26]]},"references-count":21,"journal-issue":{"issue":"4037","published-print":{"date-parts":[[1972,5,26]]}},"alternative-id":["10.1126\/science.176.4037.924"],"URL":"https:\/\/doi.org\/10.1126\/science.176.4037.924","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,5,26]]}}}