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The decrease in this hemoprotein, cytochrome P\n            <jats:sub>450<\/jats:sub>\n            , by the barbiturates containing an allyl group could also be demonstrated in an in vitro liver microsomal system requiring reduced nicotinamide adenine dinucleotide phosphate. These results suggest that the barbiturates containing an allyl group are converted to a metabolite that leads to the destruction of cytochrome P\n            <jats:sub>450<\/jats:sub>\n            .\n          <\/jats:p>","DOI":"10.1126\/science.176.4041.1341","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"1341-1343","source":"Crossref","is-referenced-by-count":41,"title":["Destruction of Cytochrome P\n            <sub>450<\/sub>\n            by Secobarbital and Other Barbiturates Containing Allyl Groups"],"prefix":"10.1126","volume":"176","author":[{"given":"W.","family":"Levin","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sernatinger","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kuntzman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"281","volume":"4","year":"1971","unstructured":"ABBRITTI, G, CHEM-BIOL INTERACT 4: 281 (1971).","journal-title":"CHEM-BIOL INTERACT"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1749-6632.1971.tb46887.x","volume":"179","year":"1971","unstructured":"BRODIE, B.B., DRUG METABOLISM IN MAN - 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