{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:10:16Z","timestamp":1790647816026,"version":"4.1.0"},"reference-count":7,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4043","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1972,7,7]]},"abstract":"<jats:p>\n            11-Hydroxy-\u0394\n            <jats:sup>9<\/jats:sup>\n            -tetrahydrocannabinol, administered intravenously to man, produces psychologic and pharmacologic effects that persist for several hours. The drug and its metabolites are excreted in urine and feces for more than 1 week. The pharmacology, disposition, and metabolism of 11-hydroxy-\u0394\n            <jats:sup>9<\/jats:sup>\n            -tetrahydrocannabinol mimic that of \u0394\n            <jats:sup>9<\/jats:sup>\n            -tetrahydrocannabinol, thus providing evidence that \u0394\n            <jats:sup>9<\/jats:sup>\n            -tetrahydrocannabinol (the major active component of marihuana) is converted to the 11-hydroxy compound in man, the latter compound being responsible for the effects.\n          <\/jats:p>","DOI":"10.1126\/science.177.4043.62","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"62-64","source":"Crossref","is-referenced-by-count":114,"title":["11-Hydroxy-\u0394\n            <sup>9<\/sup>\n            -tetrahydrocannabinol: Pharmacology, Disposition, and Metabolism of a Major Metabolite of Marihuana in Man"],"prefix":"10.1126","volume":"177","author":[{"given":"Louis","family":"Lemberger","sequence":"first","affiliation":[{"name":"Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Indiana 46202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross E.","family":"Crabtree","sequence":"additional","affiliation":[{"name":"Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Indiana 46202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard M.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Indiana 46202"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"698","volume":"8","year":"1971","unstructured":"AGURELL, S, METABOLISM OF 7-HYDROXY-DELTA-1(6)-THC AND CBN, ACTA PHARMACEUTICA SUECICA 8: 698 (1971).","journal-title":"ACTA PHARMACEUTICA SUECICA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0006-2952(70)90048-1","volume":"19","year":"1970","unstructured":"AGURELL, S, ON METABOLISM OF TRITIUM-LABELLED DELTA 1-TETRAHYDROCANNABINOL IN RABBIT, BIOCHEMICAL PHARMACOLOGY 19: 1333 (1970).","journal-title":"BIOCHEMICAL PHARMACOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3979.165"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1749-6632.1971.tb13994.x","volume":"191","year":"1971","unstructured":"LEMBERGER, L, METABOLISM AND DISPOSITION OF TETRAHYDROCANNABINOLS IN NAIVE SUBJECTS AND CHRONIC MARIHUANA USERS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 191: 142 (1971).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1054-3589(08)60525-6","volume":"10","year":"1972","unstructured":"Lemberger, L., Advances in Pharmacology and Chemotherapy 10: 221 (1972).","journal-title":"Advances in Pharmacology and Chemotherapy"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM197203302861303","volume":"286","year":"1972","unstructured":"LEMBERGER, L, DELTA-9-TETRAHYDROCANNABINOL - TEMPORAL CORRELATION OF PSYCHOLOGIC EFFECTS AND BLOOD LEVELS AFTER VARIOUS ROUTES OF ADMINISTRATION, NEW ENGLAND JOURNAL OF MEDICINE 286: 685 (1972).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3936.1159"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.177.4043.62","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:41:12Z","timestamp":1704984072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.177.4043.62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,7,7]]},"references-count":7,"journal-issue":{"issue":"4043","published-print":{"date-parts":[[1972,7,7]]}},"alternative-id":["10.1126\/science.177.4043.62"],"URL":"https:\/\/doi.org\/10.1126\/science.177.4043.62","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,7,7]]}}}