{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:26:54Z","timestamp":1776727614054,"version":"3.51.2"},"reference-count":19,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4050","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1972,8,25]]},"abstract":"<jats:p>Histamine insolubilized by chemical linkage via a protein or polypeptide carrier to Sepharose beads cannot penetrate cells. Even so, the resultant histamine-coated Sepharose binds leukocytes selectively. Despite the low molecular weight of histamine, the binding is via preformed cell membrane receptors and can be specifically and competitively blocked or reversed by antihistamines.<\/jats:p>","DOI":"10.1126\/science.177.4050.707","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"707-709","source":"Crossref","is-referenced-by-count":74,"title":["Receptors for Histamine Can Be Detected on the Surface of Selected Leukocytes"],"prefix":"10.1126","volume":"177","author":[{"given":"Kenneth L.","family":"Melmon","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pharmacology, University of California School of Medicine, San Francisco 94122"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry R.","family":"Bourne","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology, University of California School of Medicine, San Francisco 94122"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of Chemical Immunology, Weizmann Institute of Science, Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sela","sequence":"additional","affiliation":[{"name":"Department of Chemical Immunology, Weizmann Institute of Science, Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.4049\/jimmunol.108.3.695","volume":"108","year":"1972","unstructured":"Bourne, H. R, Journal of Immunology 108: 695 (1972).","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1172\/JCI106564","volume":"50","year":"1971","unstructured":"BOURNE, H.R., CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE IN HUMAN LEUKOCYTE - SYNTHESIS, DEGRADATION, AND EFFECTS ON NEUTROPHIL CANDIDACIDAL ACTIVITY, JOURNAL OF CLINICAL INVESTIGATION 50: 920 (1971).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_3_1","first-page":"1","volume":"178","year":"1971","unstructured":"BOURNE, H.R., ADENYL CYCLASE IN HUMAN LEUKOCYTES - EVIDENCE FOR ACTIVATION BY SEPARATE BETA ADRENERGIC AND PROSTAGLANDIN RECEPTORS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 178: 1 (1971).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.3998.743"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.bi.40.070171.001355","volume":"40","year":"1971","unstructured":"CUATRECASAS, P, AFFINITY CHROMATOGRAPHY, ANNUAL REVIEW OF BIOCHEMISTRY 40: 259 (1971).","journal-title":"ANNUAL REVIEW OF BIOCHEMISTRY"},{"key":"e_1_2_1_6_1","first-page":"450","volume":"63","year":"1969","unstructured":"CUATRECASAS, P, INTERACTION OF INSULIN WITH CELL MEMBRANE - PRIMARY ACTION OF INSULIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 63: 450 (1969).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-5793(72)80022-X","volume":"20","year":"1972","unstructured":"HECHT, J.P., LIPOLYTIC-ACTIVITY OF BOVINE GROWTH-HORMONE BOUND TO SEPHAROSE BEADS, FEBS LETTERS 20: 83 (1972).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1084\/jem.123.2.229","volume":"123","year":"1966","unstructured":"LESKOWITZ, S, IMMUNOCHEMICAL STUDY OF ANTIGENIC SPECIFICITY IN DELAYED HYPERSENSITIVITY .V. IMMUNIZATION WITH MONOVALENT LOW MOLECULAR WEIGHT CONJUGATES, JOURNAL OF EXPERIMENTAL MEDICINE 123: 229 (1966).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_9_1","first-page":"2066","volume":"68","year":"1971","unstructured":"OKA, T, INSULIN-SEPHAROSE AND DYNAMICS OF INSULIN ACTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 2066 (1971).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/2151491a0","volume":"215","year":"1967","unstructured":"PORATH, J, CHEMICAL COUPLING OF PROTEINS TO AGAROSE, NATURE 215: 1491 (1967).","journal-title":"NATURE"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000230224","volume":"37","year":"1970","unstructured":"PRUZANSKY, J.J., HISTAMINE IN HUMAN LEUCOCYTES . LOCALIZATION OF HISTAMINE AND BETA GLUCURONIDASE IN HUMAN LEUCOCYTES, INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY 37: 98 (1970).","journal-title":"INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY"},{"key":"e_1_2_1_12_1","first-page":"909","volume":"68","year":"1971","unstructured":"RODBELL, M, REACTION OF GLUCAGON WITH ITS RECEPTOR - EVIDENCE FOR DISCRETE REGIONS OF ACTIVITY AND BINDING IN GLUCAGON MOLECULE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 909 (1971).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1021\/bi00884a028","volume":"4","year":"1965","unstructured":"SCHLOSSMAN, S.F., IMMUNOGENICITY OF A SERIES OF ALPHA N-DNP-L-LYSINES, BIOCHEMISTRY 4: 1638 (1965).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1016\/S0021-9258(18)61876-9","volume":"246","year":"1971","unstructured":"SCHORR, I, MULTIPLE SPECIFIC HORMONE RECEPTORS IN ADENYLATE CYCLASE OF AN ADRENOCORTICAL CARCINOMA, JOURNAL OF BIOLOGICAL CHEMISTRY 246: 5806 (1971).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/2231374a0","volume":"223","year":"1969","unstructured":"SEGAL, S, SPECIFIC BLOCKING IN VITRO OF ANTIBODY SYNTHESIS BY AFFINITY LABELLING REAGENTS, NATURE 223: 1374 (1969).","journal-title":"NATURE"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/2231375a0","volume":"223","year":"1969","unstructured":"SHAFFER, C.F., TRANSFER OF IMMUNITY AGAINST LONG SURVIVING RAT SKIN XENOGRAFTS BY ANTILYMPHOCYTE SERUM TREATED SYRIAN HAMSTERS, NATURE 223: 1375 (1969).","journal-title":"NATURE"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.4049\/jimmunol.106.3.721","volume":"106","year":"1971","unstructured":"SULICA, A, DETECTION OF ANTIBODY-LIKE STRUCTURES ON CELL SURFACES WITH CHEMICALLY MODIFIED BACTERIOPHAGES, JOURNAL OF IMMUNOLOGY 106: 721 (1971).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_18_1","first-page":"685","volume":"66","year":"1970","unstructured":"TRUFFBACHI, P, SPECIFIC SEPARATION OF CELLS ON AFFINITY COLUMNS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 66: 685 (1970).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1084\/jem.129.1.23","volume":"129","year":"1969","unstructured":"WIGZELL, H, CELL SEPARATION ON ANTIGEN-COATED COLUMNS - ELIMINATION OF HIGH RATE ANTIBODY-FORMING CELLS AND IMMUNOLOGICAL MEMORY CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 129: 23 (1969).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.177.4050.707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:09:56Z","timestamp":1704982196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.177.4050.707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,8,25]]},"references-count":19,"journal-issue":{"issue":"4050","published-print":{"date-parts":[[1972,8,25]]}},"alternative-id":["10.1126\/science.177.4050.707"],"URL":"https:\/\/doi.org\/10.1126\/science.177.4050.707","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,8,25]]}}}