{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:31:40Z","timestamp":1771644700564,"version":"3.50.1"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4054","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1972,9,22]]},"abstract":"<jats:p>Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normal in the early phase of renovascular hypertension. These results offer strong evidence that the renin-angiotensin system is responsible for the initiation of hypertension in the unilaterally nephrectomized dog with renal artery constriction.<\/jats:p>","DOI":"10.1126\/science.177.4054.1108","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"1108-1109","source":"Crossref","is-referenced-by-count":81,"title":["Inhibition of Angiotensin Conversion in Experimental Renovascular Hypertension"],"prefix":"10.1126","volume":"177","author":[{"suffix":"Jr.","given":"Edward D.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Physiology, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan I.","family":"Samuels","sequence":"additional","affiliation":[{"name":"Department of Physiology, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Haber","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, and Medical Services, Massachusetts General Hospital, Boston 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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