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It is presumed that these psychological changes were directly or indirectly produced from increases in brain serotonin. Indirect data from animals and humans indicate that there may be an abnormality in serotonin metabolism in some schizophrenics. While our data are consistent with this hypothesis, other explanations for our data must be entertained.<\/jats:p>","DOI":"10.1126\/science.177.4054.1124","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"1124-1126","source":"Crossref","is-referenced-by-count":58,"title":["Behavioral Changes of Chronic Schizophrenic Patients Given L-5-Hydroxytryptophan"],"prefix":"10.1126","volume":"177","author":[{"given":"Richard J.","family":"Wyatt","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research. National Institute of Mental Health. 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