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After typhoid vaccine is administered to the unanesthetized cat,\n            <jats:sup>45<\/jats:sup>\n            Ca\n            <jats:sup>2+<\/jats:sup>\n            efflux into the third cerebral ventricle increases while\n            <jats:sup>22<\/jats:sup>\n            Na\n            <jats:sup>+<\/jats:sup>\n            is retained in hypothalamic tissue at the same time that the set-point temperature begins to rise. The subsequent rates of\n            <jats:sup>22<\/jats:sup>\n            Na\n            <jats:sup>+<\/jats:sup>\n            and\n            <jats:sup>45<\/jats:sup>\n            Ca\n            <jats:sup>2+<\/jats:sup>\n            efflux parallel the course of the bacterial fever but in a reciprocal fashion. This supports the theory that a change in the set-point temperature is determined by an alteration in the inherent ratio of Na\n            <jats:sup>+<\/jats:sup>\n            to Ca\n            <jats:sup>2+<\/jats:sup>\n            ions in the hypothalamus.\n          <\/jats:p>","DOI":"10.1126\/science.178.4062.765","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"765-767","source":"Crossref","is-referenced-by-count":32,"title":["Fever: Reciprocal Shift in Brain Sodium to Calcium Ratio as the Set-Point Temperature Rises"],"prefix":"10.1126","volume":"178","author":[{"given":"R. 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