{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:02:05Z","timestamp":1769266925185,"version":"3.49.0"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4066","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1972,12,15]]},"abstract":"<jats:p>Chemical data are presented from a comparison study of the smoke of cigarettes and little cigars. The tobacco products and their mainstream smokes were analyzed for a number of toxic constituents in an effort to define \"smoke inhalability.\" This issue has particular public health importance because the difference in the inhalability of cigar and cigarette smoke is generally assumed to account for the differences in the health risk to the individual smoker.<\/jats:p>","DOI":"10.1126\/science.178.4066.1197","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:03:38Z","timestamp":1160057018000},"page":"1197-1199","source":"Crossref","is-referenced-by-count":31,"title":["Smoke of Cigarettes and Little Cigars: An Analytical Comparison"],"prefix":"10.1126","volume":"178","author":[{"given":"Dietrich","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Health Research Institute, American Health Foundation, New York 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest L.","family":"Wynder","sequence":"additional","affiliation":[{"name":"Health Research Institute, American Health Foundation, New York 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"759","year":"1972","unstructured":"Code of Federal Regulations 26, part 270, Manufacture of Cigars and Cigarettes: 759 (1972).","journal-title":"Code of Federal Regulations 26, part 270, Manufacture of Cigars and Cigarettes"},{"key":"e_1_2_1_2_1","unstructured":"Royal College of Physicians Smoking and HealtH (1962)."},{"key":"e_1_2_1_3_1","unstructured":"Royal College of Physicians Smoking and Health Now (1971)."},{"key":"e_1_2_1_4_1","unstructured":"U.S. PUBLIC HEALTH REPORT 1103 (1964)."},{"issue":"1225","key":"e_1_2_1_5_1","first-page":"117","year":"1969","unstructured":"U.S. DEPARTMENT OF AGRICULTURE TECHNICAL BULLETIN 1225 117 (1969).","journal-title":"U.S. DEPARTMENT OF AGRICULTURE TECHNICAL BULLETIN"},{"key":"e_1_2_1_6_1","unstructured":"U.S. PUBLIC HEALTH REPORT 1696-Suppl. (1968)."},{"key":"e_1_2_1_7_1","unstructured":"U.S. PUBLIC HEALTH REPORT 1696 (1967)."},{"key":"e_1_2_1_8_1","unstructured":"U.S. PUBLIC HEALTH REPORT 1696-2 (1969)."},{"key":"e_1_2_1_9_1","unstructured":"HEW PUBLICATION 71-7513 (1971)."},{"key":"e_1_2_1_10_1","unstructured":"HEW PUBLICATION 72-1516 (1972)."},{"key":"e_1_2_1_11_1","first-page":"58","volume":"5","year":"1969","unstructured":"ARTHO, A, BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL 5: 58 (1969).","journal-title":"BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL"},{"key":"e_1_2_1_12_1","unstructured":"HOFFMAN D UNPUBLISHED DATA."},{"key":"e_1_2_1_13_1","first-page":"101","volume":"1","year":"1961","unstructured":"HOFFMANN, D, BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL 1: 101 (1961).","journal-title":"BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL"},{"key":"e_1_2_1_14_1","first-page":"172","volume":"27","year":"1967","unstructured":"HOFFMANN, D, REDUCTION OF TUMORIGENICITY OF CIGARETTE SMOKE CONDENSATE BY ADDITION OF SODIUM NITRATE TO TOBACCO, CANCER RESEARCH 27: 172 (1967).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_15_1","first-page":"67","volume":"30","year":"1963","unstructured":"HOFFMANN, D, FILTRATION OF PHENOLS FROM CIGARETTE SMOKE, JOURNAL OF THE NATIONAL CANCER INSTITUTE 30: 67 (1963).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_16_1","first-page":"151","volume":"28","year":"1968","unstructured":"HOFFMANN, D, NATIONAL CANCER INSTITUTE MONOGRAPHS 28: 151 (1968).","journal-title":"NATIONAL CANCER INSTITUTE MONOGRAPHS"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/jama.1950.02910390008002","volume":"143","year":"1950","unstructured":"LEVIN, M.L., CANCER AND TOBACCO SMOKING - A PRELIMINARY REPORT, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 143: 336 (1950).","journal-title":"JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION"},{"key":"e_1_2_1_18_1","first-page":"20","volume":"98","year":"1971","unstructured":"MAXWELL, J.C., TOB REP 98: 20 (1971).","journal-title":"TOB REP"},{"key":"e_1_2_1_19_1","first-page":"458","volume":"52","year":"1969","unstructured":"PILLSBURY, H.C., TAR AND NICOTINE IN CIGARETTE SMOKE, JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS 52: 458 (1969).","journal-title":"JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS"},{"key":"e_1_2_1_20_1","first-page":"302","volume":"5","year":"1970","unstructured":"RATHKAMP, G, BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL 5: 302 (1970).","journal-title":"BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL"},{"key":"e_1_2_1_21_1","first-page":"75","volume":"10","year":"1966","unstructured":"SCHULTZ, F.J., TOBACCO SCIENCE 10: 75 (1966).","journal-title":"TOBACCO SCIENCE"},{"key":"e_1_2_1_22_1","first-page":"25","volume":"11","year":"1967","unstructured":"SENSABAUGH, A.J., TOBACCO SCIENCE 11: 25 (1967).","journal-title":"TOBACCO SCIENCE"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/jama.1950.02910390001001","volume":"143","year":"1950","unstructured":"WYNDER, E.L., TOBACCO SMOKING AS A POSSIBLE ETIOLOGIC FACTOR IN BRONCHIOGENIC CARCINOMA - A STUDY OF 684 PROVED CASES, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 143: 329 (1950).","journal-title":"JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","unstructured":"WYNDER E.L. TABACCO TOBACCO SMOK (1968).","DOI":"10.1038\/219661b0"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.178.4066.1197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T21:56:44Z","timestamp":1705010204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.178.4066.1197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,12,15]]},"references-count":24,"journal-issue":{"issue":"4066","published-print":{"date-parts":[[1972,12,15]]}},"alternative-id":["10.1126\/science.178.4066.1197"],"URL":"https:\/\/doi.org\/10.1126\/science.178.4066.1197","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,12,15]]}}}