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Induction of the enzyme is related to the dose of 2,3,7,8-tetrachlorodibenzo-<jats:italic>p<\/jats:italic>-dioxin and, in contrast to that produced with other drugs, is prolonged in time, with 70 percent of the maximum induced activity present 5 days after a single dose. This contaminant is implicated as the likely causative agent in an outbreak of porphyria cutanea tarda in workers in a factory where 2,4,5-trichlorophenoxyacetic acid was being synthesized.<\/jats:p>","DOI":"10.1126\/science.179.4072.476","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"476-477","source":"Crossref","is-referenced-by-count":109,"title":["2,3,7,8-Tetrachlorodibenzo-<i>p<\/i>-dioxin: A Potent Inducer of \u03b4-Aminolevulinic Acid Synthetase"],"prefix":"10.1126","volume":"179","author":[{"given":"Alan","family":"Poland","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Glover","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"Report on 2 4 5-T. 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