{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:32:31Z","timestamp":1767706351705},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4082","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1973,4,13]]},"abstract":"<jats:p>\n            The 1\u03b1-hydroxy derivative of vitamin D\n            <jats:sub>3<\/jats:sub>\n            has been chemically synthesized and tested for its biological activity. This analog has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D\n            <jats:sub>3<\/jats:sub>\n            in the stimulation of intestinal calcium transport and bone calcium mobilization in normal and anephric rats. Because the 1\u03b1-hydroxy derivative is synthesized from cholesterol, it is easier and less expensive to prepare than 1\u03b1,25-dihydroxy derivative, making it attractive as a drug in the treatment of renal osteodystrophy and hypoparathyroidism.\n          <\/jats:p>","DOI":"10.1126\/science.180.4082.190","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"190-191","source":"Crossref","is-referenced-by-count":162,"title":["1\u03b1-Hydroxy Derivative of Vitamin D\n            <sub>3<\/sub>\n            : A Highly Potent Analog of 1\u03b1,25-Dihydroxyvitamin D\n            <sub>3<\/sub>"],"prefix":"10.1126","volume":"180","author":[{"given":"M. F.","family":"Holick","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Agricultutral and Life Sciences, University of Wisconsin, Madison 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J.","family":"Semmler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Agricultutral and Life Sciences, University of Wisconsin, Madison 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. K.","family":"Schnoes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Agricultutral and Life Sciences, University of Wisconsin, Madison 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. F.","family":"Deluca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Agricultutral and Life Sciences, University of Wisconsin, Madison 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1021\/bi00850a001","volume":"7","year":"1968","unstructured":"BLUNT, J.W., 25-HYDROXYCHOLECALCIFEROL . A BIOLOGICALLY ACTIVE METABOLITE OF VITAMIN D3, BIOCHEMISTRY 7: 3317 (1968).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_2_1","first-page":"1503","volume":"61","year":"1968","unstructured":"BLUNT, J.W., BIOLOGICAL ACTIVITY OF 25-HYDROXYCHOLECALCIFEROL A METABOLITE OF VITAMIN D3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 61: 1503 (1968).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1210\/endo-90-3-605","volume":"90","year":"1972","unstructured":"BOYLE, I.T., RESPONSE OF INTESTINAL CALCIUM TRANSPORT TO 25-HYDROXY AND 1,25-DIHYDROXY VITAMIN-D IN NEPHRECTOMIZED RATS, ENDOCRINOLOGY 90: 605 (1972).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/228764a0","volume":"228","year":"1970","unstructured":"FRASER, D.R., UNIQUE BIOSYNTHESIS BY KIDNEY OF A BIOLOGICALLY ACTIVE VITAMIN-D METABOLITE, NATURE 228: 764 (1970).","journal-title":"NATURE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1172\/JCI107114","volume":"51","year":"1972","unstructured":"FROLIK, C.A., METABOLISM OF 1,25-DIHYDROXYCHOLECALCIFEROL IN RAT, JOURNAL OF CLINICAL INVESTIGATION 51: 2900 (1972).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3989.1232"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1152\/ajplegacy.1963.204.5.833","volume":"204","year":"1963","unstructured":"GUROFF, G, CITRATE AND ACTION OF VITAMIN D ON CALCIUM AND PHOSPHORUS METABOLISM, AMERICAN JOURNAL OF PHYSIOLOGY 204: 833 (1963).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_8_1","first-page":"177","volume":"68","year":"1971","unstructured":"HAUSSLER, M.R., RAPIDLY ACTING METABOLITE OF VITAMIN-D3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 177 (1971).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1021\/bi00790a023","volume":"10","year":"1971","unstructured":"HOLICK, M.F., ISOLATION AND IDENTIFICATION OF 1,25-DIHYDROXYCHOLECALCIFEROL - METABOLITE OF VITAMIN-D ACTIVE IN INTESTINE, BIOCHEMISTRY 10: 2799 (1971).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1021\/bi00764a026","volume":"11","year":"1972","unstructured":"HOLICK, M.F., 5,6-TRANS ISOMERS OF CHOLECALCIFEROL AND 25-HYDROXYCHOLECALCIFEROL - SUBSTITUTES FOR 1,25-DIHYDROXYCHOLECALCIFEROL IN ANEPHRIC ANIMALS, BIOCHEMISTRY 11: 2715 (1972).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_11_1","first-page":"803","volume":"68","year":"1971","unstructured":"HOLICK, M.F., IDENTIFICATION OF 1,25-DIHYDROXYCHOLECALCIFEROL, A FORM OF VITAMIN-D3 METABOLICALLY ACTIVE IN INTESTINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 803 (1971).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4039.1146"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0006-291X(69)90322-2","volume":"36","year":"1969","unstructured":"HORSTING, M, IN VITRO PRODUCTION OF 25-HYDROXYCHOLECALCIFEROL, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 36: 251 (1969).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/230228a0","volume":"230","year":"1971","unstructured":"LAWSON, DEM, IDENTIFICATION OF 1,25-DIHYDROXYCHOLECALCIFEROL, A NEW KIDNEY HORMONE CONTROLLING CALCIUM METABOLISM, NATURE 230: 228 (1971).","journal-title":"NATURE"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3966.79"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/0006-291X(71)90015-5","volume":"42","year":"1971","unstructured":"NORMAN, A.W., STUDIES ON CALCIFEROL METABOLISM .1. PRODUCTION OF VITAMIN-D METABOLITE-4B FROM 25-OH-CHOLECALCIFEROL BY KIDNEY HOMOGENATES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42: 1082 (1971).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1021\/bi00791a022","volume":"10","year":"1971","unstructured":"OMDAHL, J, BIOLOGICAL ACTIVITY OF 1,25-DIHYDROXYCHOLECALCIFEROL, BIOCHEMISTRY 10: 2935 (1971).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1172\/JCI106168","volume":"48","year":"1969","unstructured":"PONCHON, G, ACTIVATION OF VITAMIN D BY LIVER, JOURNAL OF CLINICAL INVESTIGATION 48: 2032 (1969).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_19_1","first-page":"4147","year":"1972","unstructured":"SEMMLER, E.J., SYNTHESIS OF 1 ALPHA, 25-DIHYDROXYCHOLECALCIFEROL - METABOLICALLY ACTIVE FORM OF VITAMIN-D3, TETRAHEDRON LETTERS: 4147 (1972).","journal-title":"TETRAHEDRON LETTERS"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0003-9861(71)90163-9","volume":"146","year":"1971","unstructured":"TANAKA, Y, BONE MINERAL MOBILIZATION ACTIVITY OF 1,25-DIHYDROXYCHOLECALCIFEROL, A METABOLITE OF VITAMIN-D, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 146: 574 (1971).","journal-title":"ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/jn\/102.12.1569","volume":"102","year":"1972","unstructured":"Tanaka, Y., Journal of Nutrition 102: 1569 (1972).","journal-title":"Journal of Nutrition"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.180.4082.190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T21:01:20Z","timestamp":1705006880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.180.4082.190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4,13]]},"references-count":21,"journal-issue":{"issue":"4082","published-print":{"date-parts":[[1973,4,13]]}},"alternative-id":["10.1126\/science.180.4082.190"],"URL":"https:\/\/doi.org\/10.1126\/science.180.4082.190","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,4,13]]}}}