{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:58:38Z","timestamp":1790355518099,"version":"4.1.0"},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4082","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1973,4,13]]},"abstract":"<jats:p>DNA polymerases have been partially purified from human milk. A DNA polymerase detected by phosphocellulose chromatography is similar to the enzymes of RNA tumor viruses in that a hybrid of polyriboadenylate and oligodeoxythymidylate is a better template than is DNA. However, this polymerase differed from that of the RNA tumor viruses in its chromatographic behavior. Three different methods of detecting \"reverse transcriptase\" activity failed to correlate with the donor's family history of cancer.<\/jats:p>","DOI":"10.1126\/science.180.4082.198","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"198-201","source":"Crossref","is-referenced-by-count":25,"title":["DNA Polymerase Activities of Human Milk"],"prefix":"10.1126","volume":"180","author":[{"given":"Brenda I.","family":"Gerwin","sequence":"first","affiliation":[{"name":"Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Ebert","sequence":"additional","affiliation":[{"name":"Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish C.","family":"Chopra","sequence":"additional","affiliation":[{"name":"Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan G.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Kvedar","sequence":"additional","affiliation":[{"name":"Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Albert","sequence":"additional","affiliation":[{"name":"Michigan Cancer Foundation, Detroit 48201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Michigan Cancer Foundation, Detroit 48201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"159","volume":"243","year":"1973","unstructured":"Chopra, H., Nature New Biology 243: 159 (1973).","journal-title":"Nature New Biology"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/newbio239092a0","volume":"239","year":"1972","unstructured":"DAS, M.R., HOMOLOGY BETWEEN RNA FROM HUMAN MALIGNANT BREAST TISSUE AND DNA SYNTHESIZED BY MILK PARTICLES, NATURE-NEW BIOLOGY 239: 92 (1972).","journal-title":"NATURE-NEW BIOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/1097-0142(196912)24:6<1250::AID-CNCR2820240631>3.0.CO;2-F","volume":"24","year":"1969","unstructured":"FELLER, W.F., STUDIES OF HUMAN MILK IN RELATION TO POSSIBLE VIRAL ETIOLOGY OF BREAST CANCER, CANCER 24: 1250 (1969).","journal-title":"CANCER"},{"key":"e_1_2_1_4_1","first-page":"452","volume":"69","year":"1972","unstructured":"FRIDLENDER, B, NEW SYNTHETIC RNA-DEPENDENT DNA POLYMERASE FROM HUMAN TISSUE-CULTURE CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 452 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_5_1","first-page":"2599","volume":"69","year":"1972","unstructured":"GERWIN, B.I., OLIGONUCLEOTIDE AFFINITY COLUMN FOR RNA-DEPENDENT DNA POLYMERASE FROM RNA TUMOR VIRUSES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 2599 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_6_1","first-page":"2020","volume":"69","year":"1972","unstructured":"GULATI, S.C., DETECTION OF RNA-INSTRUCTED DNA POLYMERASE AND HIGH MOLECULAR-WEIGHT RNA IN MALIGNANT TISSUE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 2020 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/1097-0142(197112)28:6<1415::AID-CNCR2820280614>3.0.CO;2-Z","volume":"28","year":"1971","unstructured":"MOORE, D.H., SOME ASPECTS OF SEARCH FOR A HUMAN MAMMARY TUMOR VIRUS, CANCER 28: 1415 (1971).","journal-title":"CANCER"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/229611a0","volume":"229","year":"1971","unstructured":"MOORE, D.H., SEARCH FOR A HUMAN BREAST CANCER VIRUS, NATURE 229: 611 (1971).","journal-title":"NATURE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/236103a0","volume":"236","year":"1972","unstructured":"SARKAR, N.H., POSSIBILITY OF A HUMAN BREAST-CANCER VIRUS, NATURE 236: 103 (1972).","journal-title":"NATURE"},{"key":"e_1_2_1_10_1","first-page":"1197","volume":"48","year":"1972","unstructured":"SCHLOM, J, REVERSE TRANSCRIPTASE AND HIGH MOLECULAR-WEIGHT RNA IN PARTICLES FROM MOUSE AND HUMAN MILK, JOURNAL OF THE NATIONAL CANCER INSTITUTE 48: 1197 (1972).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/231097a0","volume":"231","year":"1971","unstructured":"SCHLOM, J, RNA-DEPENDENT DNA POLYMERASE ACTIVITY IN VIRUS-LIKE PARTICLES ISOLATED FROM HUMAN MILK, NATURE 231: 97 (1971).","journal-title":"NATURE"},{"key":"e_1_2_1_12_1","unstructured":"SCHLOM J PERSONAL COMMUNICATION."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4021.542"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/237499a0","volume":"237","year":"1972","unstructured":"WARD, D.C., SYNTHETIC RNA-DEPENDENT DNA POLYMERASE-ACTIVITY IN NORMAL RAT-LIVER AND HEPATOMAS, NATURE 237: 499 (1972).","journal-title":"NATURE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.180.4082.198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T21:01:27Z","timestamp":1705006887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.180.4082.198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4,13]]},"references-count":14,"journal-issue":{"issue":"4082","published-print":{"date-parts":[[1973,4,13]]}},"alternative-id":["10.1126\/science.180.4082.198"],"URL":"https:\/\/doi.org\/10.1126\/science.180.4082.198","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,4,13]]}}}