{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:34:42Z","timestamp":1790843682995,"version":"4.1.0"},"reference-count":9,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4085","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1973,5,4]]},"abstract":"<jats:p>Neurofibrillary degeneration is an important pathological finding in senile and presenile dementia of the Alzheimer type. Experimentally, aluminum induces neurofibrillary degeneration in neurons of higher mammals. Aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease.<\/jats:p>","DOI":"10.1126\/science.180.4085.511","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"511-513","source":"Crossref","is-referenced-by-count":690,"title":["Brain Aluminum Distribution in Alzheimer's Disease and Experimental Neurofibrillary Degeneration"],"prefix":"10.1126","volume":"180","author":[{"given":"D. R.","family":"Crapper","sequence":"first","affiliation":[{"name":"Departments of Physiology and Medicine, University of Toronto, Toronto 5, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Medicine, University of Toronto, and Center for Forensic Sciences, Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Dalton","sequence":"additional","affiliation":[{"name":"Department of Psychology, Mental Retardation Center, Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0031-9384(73)90063-2","volume":"10","year":"1973","unstructured":"Crapper, D. R., Physiology & Behavior 10: 925 (1973).","journal-title":"Physiology & Behavior"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0031-9384(73)90064-4","volume":"10","year":"1973","unstructured":"Crapper, D. R., Physiology & Behavior 10: 935 (1973).","journal-title":"Physiology & Behavior"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005072-196504000-00002","volume":"24","year":"1965","unstructured":"KLATZO, I, EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION .I. LIGHT MICROSCOPIC OBSERVATIONS, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 24: 187 (1965).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1176\/ajp.98.6.881","volume":"98","year":"1942","unstructured":"KOPELOFF, L.M., Recurrent convulsive seizures in animals produced by immunologic and chemical means, AMERICAN JOURNAL OF PSYCHIATRY 98: 881 (1942).","journal-title":"AMERICAN JOURNAL OF PSYCHIATRY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/ac60316a019","volume":"44","year":"1972","unstructured":"KRISHNAN, S.S., DETERMINATION OF ALUMINUM IN BIOLOGICAL-MATERIAL BY ATOMIC-ABSORPTION SPECTROPHOTOMETRY, ANALYTICAL CHEMISTRY 44: 1469 (1972).","journal-title":"ANALYTICAL CHEMISTRY"},{"key":"e_1_2_1_6_1","first-page":"253","volume":"19","year":"1962","unstructured":"MCLAUGHLIN, AIG, PULMONARY FIBROSIS AND ENCEPHALOPATHY ASSOCIATED WITH INHALATION OF ALUMINIUM DUST, BRITISH JOURNAL OF INDUSTRIAL MEDICINE 19: 253 (1962).","journal-title":"BRITISH JOURNAL OF INDUSTRIAL MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00005072-196310000-00005","volume":"22","year":"1963","unstructured":"TERRY, R.D., FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERS DISEASE, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 22: 629 (1963).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00005072-196504000-00003","volume":"24","year":"1965","unstructured":"TERRY, R.D., EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION .2. ELECTRON MICROSCOPY PHOSPHATASE HISTOCHEMISTRY AND ELECTRON PROBE ANALYSIS, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 24: 200 (1965).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00005072-197004000-00001","volume":"29","year":"1970","unstructured":"WISNIEWSKI, H, NEUROFIBRILLARY PATHOLOGY, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 29: 163 (1970).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.180.4085.511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T21:04:49Z","timestamp":1705007089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.180.4085.511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,5,4]]},"references-count":9,"journal-issue":{"issue":"4085","published-print":{"date-parts":[[1973,5,4]]}},"alternative-id":["10.1126\/science.180.4085.511"],"URL":"https:\/\/doi.org\/10.1126\/science.180.4085.511","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,5,4]]}}}