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Much lesser but still significant falls in blood pressure were also produced in normotensive sodium-depleted rats but not in repleted rats. We conclude that the importance of angiotensin for maintaining blood pressure is largely determined by its relation to available sodium or fluid volume, since the renin component in maintenance of either the hypertensive or the normotensive state could be exposed only by sodium deprivation. Therefore, volume expansion per se or other pressor factors may be involved in maintaining blood pressure of these sodium-replete normotensive or hypertensive animals.<\/jats:p>","DOI":"10.1126\/science.180.4093.1369","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"1369-1372","source":"Crossref","is-referenced-by-count":185,"title":["Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats"],"prefix":"10.1126","volume":"180","author":[{"given":"Haralambos","family":"Gavras","sequence":"first","affiliation":[{"name":"Department of Medicine, Columbia University, College of Physicians and Surgeons New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans R.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University, College of Physicians and Surgeons New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"E. Darracott","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University, College of Physicians and Surgeons New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Laragh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University, College of Physicians and Surgeons New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1172\/JCI105118","volume":"44","year":"1965","unstructured":"AMES, R.P., JOURNAL OF CLINICAL INVESTIGATION 44: 117 (1965).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/cs0380741","volume":"38","year":"1970","unstructured":"BIANCHI, G, EFFECT IN CONSCIOUS DOG OF CONSTRICTION OF RENAL ARTERY TO A SOLE REMAINING KIDNEY ON HAEMODYNAMICS, SODIUM BALANCE, BODY FLUID VOLUMES, PLASMA RENIN CONCENTRATION AND PRESSOR RESPONSIVENESS TO ANGIOTENSIN, CLINICAL SCIENCE 38: 741 (1970).","journal-title":"CLINICAL SCIENCE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1161\/01.RES.18.5.475","volume":"18","year":"1966","unstructured":"BROWN, T.C., RELATION OF PLASMA RENIN TO SODIUM BALANCE AND ARTERIAL PRESSURE IN EXPERIMENTAL RENAL HYPERTENSION, CIRCULATION RESEARCH 18: 475 (1966).","journal-title":"CIRCULATION RESEARCH"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1172\/JCI106797","volume":"51","year":"1972","unstructured":"BRUNNER, H.R., ANGIOTENSIN-II VASCULAR RECEPTORS - THEIR AVIDITY IN RELATIONSHIP TO SODIUM BALANCE, AUTONOMIC NERVOUS-SYSTEM, AND HYPERTENSION, JOURNAL OF CLINICAL INVESTIGATION 51: 58 (1972).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4016.1344"},{"key":"e_1_2_1_6_1","unstructured":"Davis J. 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