{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:17:43Z","timestamp":1790864263171,"version":"4.1.0"},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4100","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1973,8,17]]},"abstract":"<jats:p>Eighty-three percent of hamsters inoculated at birth with JC virus, a human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy, developed malignant gliomas within 6 months. Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus was isolated from five of seven tumors tested. Cells from four tumors were cultivated in vitro. These cells contained an intranuclear antigen with the characteristics of a T antigen, and this antigen was antigenically related to SV40 T antigen. Although virus was not recovered from extracts of serially cultured tumor cells, JC virus was rescued when one tumor cell line was fused with permissive cells.<\/jats:p>","DOI":"10.1126\/science.181.4100.674","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"674-676","source":"Crossref","is-referenced-by-count":244,"title":["Human Papovavirus (JC): Induction of Brain Tumors in Hamsters"],"prefix":"10.1126","volume":"181","author":[{"given":"Duard L.","family":"Walker","sequence":"first","affiliation":[{"name":"Departments of Medical Microbiology and Pathology, University of Wisconsin Medical School, Madison 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie L.","family":"Padgett","sequence":"additional","affiliation":[{"name":"Departments of Medical Microbiology and Pathology, University of Wisconsin Medical School, Madison 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele M.","family":"ZuRhein","sequence":"additional","affiliation":[{"name":"Departments of Medical Microbiology and Pathology, University of Wisconsin Medical School, Madison 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albertina E.","family":"Albert","sequence":"additional","affiliation":[{"name":"Departments of Medical Microbiology and Pathology, University of Wisconsin Medical School, Madison 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Wisconsin Agricultural and Life Sciences, Madison 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"90","volume":"4","year":"1967","unstructured":"ALLEN, V, LABORATORY DIAGNOSIS OF MYCOPLASMA PNEUMONIA IN A PUBLIC HEALTH LABORATORY, HEALTH LABORATORY SCIENCE 4: 90 (1967).","journal-title":"HEALTH LABORATORY SCIENCE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/brain\/81.1.93","volume":"81","year":"1958","unstructured":"ASTROM, K.E., PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - 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