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These increases may or may not be proportional to the rise in total CSF proteins characteristic for these diseases. Elevated binding of DNA was observed in samples from patients with hydrocephalus, epilepsy, and cortical atrophy. The technique described may be applicable to the diagnosis of a variety of diseases of the central nervous system.<\/jats:p>","DOI":"10.1126\/science.182.4109.296","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"296-297","source":"Crossref","is-referenced-by-count":17,"title":["Proteins from Human Cerebrospinal Fluid: Binding with Nucleic Acids"],"prefix":"10.1126","volume":"182","author":[{"given":"H.","family":"Kubinski","sequence":"first","affiliation":[{"name":"Division of Neurological Surgery, University Hospitals, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manucher","family":"Javid","sequence":"additional","affiliation":[{"name":"Division of Neurological Surgery, University Hospitals, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0028-3908(74)90028-8","volume":"13","year":"1974","unstructured":"Andersen, P. 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