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The morphine-produced hyperalgesia at the last-mentioned site was accompanied by stereotyped violent circular leaps, an effect of morphine not previously reported. Thus, intracerebral injections of morphine differ significantly from systemic injections and produce either analgesia or hyperalgesia, depending on site and dose.<\/jats:p>","DOI":"10.1126\/science.182.4111.490","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"490-492","source":"Crossref","is-referenced-by-count":251,"title":["Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and Dose"],"prefix":"10.1126","volume":"182","author":[{"given":"Yasuko F.","family":"Jacquet","sequence":"first","affiliation":[{"name":"New York State Research Institute for Neurochemistry and Drug Addiction, Ward's Island 10035, and Department of Psychology, John Jay College, City University of New York. 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