{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:02:02Z","timestamp":1762160522199},"reference-count":11,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4113","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1973,11,16]]},"abstract":"<jats:p>Research into the pathogenesis of alcoholic cirrhosis has suffered from the lack of an animal model of alcoholic hepatitis, considered by many to be the link between alcoholic fatty liver and cirrhosis. The entire constellation of histologic features characteristic of alcoholic hepatitis has been produced for the first time in baboons by administration of ethanol with a nutritionally adequate diet. This includes fat, necrosis. inflammation, alcoholic hyaline, fibrosis, and central hyaline sclerosis.<\/jats:p>","DOI":"10.1126\/science.182.4113.712","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"712-713","source":"Crossref","is-referenced-by-count":35,"title":["Experimental Alcoholic Hepatitis: A New Primate Model"],"prefix":"10.1126","volume":"182","author":[{"given":"Emanuel","family":"Rubin","sequence":"first","affiliation":[{"name":"Department of Pathology, Mount Sinai School of Medicine, New York 10029"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Lieber","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mount Sinai School of Medicine, and Section of Liver Disease and Nutrition, Veterans Administration Hospital, Bronx, New York 10463"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4635.1001"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.7326\/0003-4819-59-5-646","volume":"59","year":"1963","unstructured":"EDMUNDSON, H.A., ANN INTERN MED 59: 646 (1963).","journal-title":"ANN INTERN MED"},{"key":"e_1_2_1_3_1","first-page":"535","volume":"48","year":"1966","unstructured":"ISERI, O.A., ULTRASTRUCTURE OF FATTY LIVER INDUCED BY PROLONGED ETHANOL INGESTION, AMERICAN JOURNAL OF PATHOLOGY 48: 535 (1966).","journal-title":"AMERICAN JOURNAL OF PATHOLOGY"},{"key":"e_1_2_1_4_1","first-page":"9","volume":"14","year":"1967","unstructured":"LELBACH, W.K., LEBERSCHADEN BEI CHRONISCHEM ALKOHOLISMUS, ACTA HEPATO-SPLENOLOGICA 14: 9 (1967).","journal-title":"ACTA HEPATO-SPLENOLOGICA"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90151-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1172\/JCI105200","volume":"44","year":"1965","unstructured":"LIEBER, C.S., EFFECTS OF PROLONGED ETHANOL INTAKE - PRODUCTION OF FATTY LIVER DESPITE ADEQUATE DIETS, JOURNAL OF CLINICAL INVESTIGATION 44: 1009 (1965).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_7_1","first-page":"585","volume":"94","year":"1954","unstructured":"PHILLIPS, G.B., ACUTE HEPATIC INSUFFICIENCY OF THE CHRONIC ALCOHOLIC - CLINICAL AND PATHOLOGICAL STUDY, AMA ARCHIVES OF NEUROLOGY AND PSYCHIATRY 94: 585 (1954).","journal-title":"AMA ARCHIVES OF NEUROLOGY AND PSYCHIATRY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/ajcp\/25.8.889","volume":"25","year":"1955","unstructured":"POPPER, H, FLORID CIRRHOSIS - A REVIEW OF 35 CASES, AMERICAN JOURNAL OF CLINICAL PATHOLOGY 25: 889 (1955).","journal-title":"AMERICAN JOURNAL OF CLINICAL PATHOLOGY"},{"key":"e_1_2_1_9_1","first-page":"569","volume":"22","year":"1970","unstructured":"RUBIN, E, INDUCTION AND INHIBITION OF HEPATIC MICROSOMAL AND MITOCHONDRIAL ENZYMES BY ETHANOL, LABORATORY INVESTIGATION 22: 569 (1970).","journal-title":"LABORATORY INVESTIGATION"},{"key":"e_1_2_1_10_1","first-page":"199","year":"1973","unstructured":"Rubin, E., The Liver: 199 (1973).","journal-title":"The Liver"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196804182781602"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.182.4113.712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T21:52:54Z","timestamp":1705009974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.182.4113.712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,11,16]]},"references-count":11,"journal-issue":{"issue":"4113","published-print":{"date-parts":[[1973,11,16]]}},"alternative-id":["10.1126\/science.182.4113.712"],"URL":"https:\/\/doi.org\/10.1126\/science.182.4113.712","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,11,16]]}}}