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We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.\n          <\/jats:p>","DOI":"10.1126\/science.182.4114.836","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T14:05:45Z","timestamp":1160057145000},"page":"836-837","source":"Crossref","is-referenced-by-count":206,"title":["Pyrimidine Starvation Induced by Adenosine in Fibroblasts and Lymphoid Cells: Role of Adenosine Deaminase"],"prefix":"10.1126","volume":"182","author":[{"given":"Howard","family":"Green","sequence":"first","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teh-Sheng","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, 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