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The noncompetitive NMDA receptor antagonist MK-801 attenuated the development of tolerance to the analgesic effect of morphine without affecting acute morphine analgesia. In addition, MK-801 attenuated the development of morphine dependence as assessed by naloxone-precipitated withdrawal. These results suggest that NMDA receptors may be important in the development of opiate tolerance and dependence.\n                  <\/jats:p>","DOI":"10.1126\/science.1824728","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:10:16Z","timestamp":1160071816000},"page":"85-87","source":"Crossref","is-referenced-by-count":1001,"title":["Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801"],"prefix":"10.1126","volume":"251","author":[{"given":"Keith A.","family":"Trujillo","sequence":"first","affiliation":[{"name":"Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0720."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda","family":"Akil","sequence":"additional","affiliation":[{"name":"Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0720."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/276186a0","volume":"276","year":"1978","unstructured":"AGHAJANIAN, G.K., TOLERANCE OF LOCUS COERULEUS NEURONS TO MORPHINE AND SUPPRESSION OF WITHDRAWAL RESPONSE BY CLONIDINE, NATURE 276: 186 (1978).","journal-title":"NATURE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0014-2999(83)90461-2","volume":"91","year":"1983","unstructured":"ANDRADE, R, MORPHINE-TOLERANCE AND DEPENDENCE IN THE LOCUS COERULEUS - 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