{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:15:24Z","timestamp":1767960924494,"version":"3.49.0"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4121","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1974,1,18]]},"abstract":"<jats:p>The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (16\/41) of grafts from old donors and on 12 percent (5\/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.<\/jats:p>","DOI":"10.1126\/science.183.4121.217","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:10:48Z","timestamp":1160061048000},"page":"217-218","source":"Crossref","is-referenced-by-count":39,"title":["Aging Increases Susceptibility of Mouse Skin to DMBA Carcinogenesis Independent of General Immune Status"],"prefix":"10.1126","volume":"183","author":[{"given":"P.","family":"Ebbesen","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, 22 Juliane Maries Vej, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1699-0463.1953.tb00238.x","volume":"32","year":"1953","unstructured":"ANDREASEN, E, ON THE SIGNIFICANCE OF THE MOUSE HAIR CYCLE IN EXPERIMENTAL CARCINOGENESIS, ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA 32: 165 (1953).","journal-title":"ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/bjc.1958.48","volume":"12","year":"1958","unstructured":"BERENBLUM, I, BRITISH JOURNAL OF CANCER 12: 402 (1958).","journal-title":"BRITISH JOURNAL OF CANCER"},{"key":"e_1_2_1_3_1","unstructured":"DANIELLI J. F. Experimentelle Altersforschting (1956)."},{"key":"e_1_2_1_4_1","first-page":"1211","volume":"1","year":"1971","unstructured":"DILMAN, V.M., AGE-ASSOCIATED ELEVATION OF HYPOTHALAMIC THRESHOLD TO FEEDBACK CONTROL, AND ITS ROLE IN DEVELOPMENT, AGEING, AND DISEASE, LANCET 1: 1211 (1971).","journal-title":"LANCET"},{"key":"e_1_2_1_5_1","first-page":"1241","volume":"47","year":"1971","unstructured":"EBBESEN, P, RETICULOSARCOMA AND AMYLOID DEVELOPMENT IN BALB\/C MICE INOCULATED WITH SYNGENEIC CELLS FROM YOUNG AND OLD DONORS, JOURNAL OF THE NATIONAL CANCER INSTITUTE 47: 1241 (1971).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/241280a0","volume":"241","year":"1973","unstructured":"Ebbesen, P., Nature 241:280 (1973).","journal-title":"Nature"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3181\/00379727-138-36004","volume":"138","year":"1971","unstructured":"EBBESEN, P, ABROGATED THYMOMA DEVELOPMENT AND INCREASED AMYLOID DEVELOPMENT IN ESTROGENIZED MICE GRAFTED SPLEEN AND BONE MARROW CELLS, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 138: 850 (1971).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_8_1","first-page":"809","volume":"46","year":"1971","unstructured":"HANNA, M.G., DECREASING IMMUNE COMPETENCE AND DEVELOPMENT OF RETICULUM CELL SARCOMAS IN LYMPHATIC TISSUE OF AGED MICE, JOURNAL OF THE NATIONAL CANCER INSTITUTE 46: 809 (1971).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/208087a0","volume":"208","year":"1965","unstructured":"METCALF, D, MULTIPLE THYMUS GRAFTS IN AGED MICE, NATURE 208: 87 (1965).","journal-title":"NATURE"},{"key":"e_1_2_1_10_1","first-page":"231","volume":"39","year":"1967","unstructured":"TELLER, M.N., AGING AND CANCERIGENESIS .4. INTERRELATIONSHIPS AMONG AGE IMMUNE RESPONSE AND TUMOR INCIDENCE IN SEVERAL STRAINS OF MICE, JOURNAL OF THE NATIONAL CANCER INSTITUTE 39: 231 (1967).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.183.4121.217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T20:15:00Z","timestamp":1705004100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.183.4121.217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1,18]]},"references-count":10,"journal-issue":{"issue":"4121","published-print":{"date-parts":[[1974,1,18]]}},"alternative-id":["10.1126\/science.183.4121.217"],"URL":"https:\/\/doi.org\/10.1126\/science.183.4121.217","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1,18]]}}}