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These observations and those in other laboratories support the assumption that dopamine formed from L-dopa selectively activates striatal adenylate cyclase. The in vivo activation of adenylate cyclase after treatment with L-dopa may be a useful model for studying neurological and psychiatric disorders that are thought to involve the dopaminergic system of the brain.<\/jats:p>","DOI":"10.1126\/science.183.4124.532","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:10:48Z","timestamp":1160061048000},"page":"532-533","source":"Crossref","is-referenced-by-count":37,"title":["Cyclic Adenosine Monophosphate: Selective Increase in Caudate Nucleus after Administration of L-Dopa"],"prefix":"10.1126","volume":"183","author":[{"given":"E.","family":"Garelis","sequence":"first","affiliation":[{"name":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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