{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:32:21Z","timestamp":1760887941087},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4124","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1974,2,8]]},"abstract":"<jats:p>Antiserum to cerebroside was prepared in rabbits by injection of cerebroside together with bovine serum albumin in complete Freund's adjuvant. When applied to cultures of embryo mouse spinal cord at explantation, this antiserum inhibited sulfatide synthesis and myelination; when applied to myelinated cultures it inhibited sulfatide synthesis and produced demyelination. Complement fixation assays also show antibody to cerebroside in serums from rabbits with experimental allergic encephalomyelitis induced by injection of whole white matter. Absorption of such serum with cerebroside abolishes the inhibiting and demyelinating activities.<\/jats:p>","DOI":"10.1126\/science.183.4124.540","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:10:48Z","timestamp":1160061048000},"page":"540-542","source":"Crossref","is-referenced-by-count":173,"title":["Cerebroside Antibody Inhibits Sulfatide Synthesis and Myelination and Demyelinates in Cord Tissue Cultures"],"prefix":"10.1126","volume":"183","author":[{"given":"June M.","family":"Fry","sequence":"first","affiliation":[{"name":"Department of Neurology, Division of Neurochemistry, Mount Sinai School of Medicine of the City University of New York, New York 10029"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulamith","family":"Weissbarth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neurochemistry, Mount Sinai School of Medicine of the City University of New York, New York 10029"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard M.","family":"Lehrer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neurochemistry, Mount Sinai School of Medicine of the City University of New York, New York 10029"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray B.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, and Rose F. Kennedy Center for Research in Mental Retardation and Human Development, New York 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.119.2.303"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196101000-00009"},{"key":"e_1_2_1_3_1","first-page":"536","volume":"23","year":"1970","unstructured":"BORNSTEIN, M.B., EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - ANTISERUM INHIBITION OF MYELINATION IN-VITO, LABORATORY INVESTIGATION 23: 536 (1970).","journal-title":"LABORATORY INVESTIGATION"},{"key":"e_1_2_1_4_1","unstructured":"BORNSTEIN M.B. UNPUBLISHED RESULTS."},{"key":"e_1_2_1_5_1","first-page":"331","volume":"5","year":"1970","unstructured":"DUBOISDALCQ, M, ACTION OF ANTI-CEREBROSIDE SERA ON MYELINATED NERVOUS TISSUE CULTURES, PATHOLOGIA EUROPAEA 5: 331 (1970).","journal-title":"PATHOLOGIA EUROPAEA"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","year":"1957","unstructured":"FOLCH, J, A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES, JOURNAL OF BIOLOGICAL CHEMISTRY 226: 497 (1957).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1471-4159.1974.tb07614.x","volume":"22","year":"1974","unstructured":"Fry, J. M., Journal of Neurochemistry 22: 459 (1974).","journal-title":"Journal of Neurochemistry"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4018.192"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/197060a0","volume":"197","year":"1963","unstructured":"JOFFE, S, IDENTIFICATION OF AN ORGAN SPECIFIC LIPID HAPTEN IN BRAIN, NATURE 197: 60 (1963).","journal-title":"NATURE"},{"key":"e_1_2_1_10_1","unstructured":"KIES M.W. CHEMICAL PATHOLOGY N (1961)."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4074.689"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1749-6632.1965.tb20210.x","volume":"122","year":"1965","unstructured":"NIEDICK, B, IMMUNOCHEMICAL AND SEROLOGICAL STUDIES ON LIPID HAPTEN OF MYELIN WITH RELATIONSHIP TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE), ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 122: 266 (1965).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/BF01478025","volume":"41","year":"1963","unstructured":"NIEDIECK, B, IMMUNOCHEMISCHE UNTERSUCHUNGEN ZUR IDENTIFIZIERUNG EINES ATHANOLLOSLICHEN MYELINHAPTENS, KLINISCHE WOCHENSCHRIFT 41: 773 (1963).","journal-title":"KLINISCHE WOCHENSCHRIFT"},{"key":"e_1_2_1_15_1","first-page":"470","volume":"125","year":"1963","unstructured":"NIEDIECK, B, ZUR SEROLOGIE DER EXPERIMENTELLEN ALLERGISCHEN ENCEPHALOMYELITIS .1. VERGLEICH DER REAKTIVITAT VON LIPIDGEMISCHEN UND MYELINEXTRAKTEN MIT DEN ENTSPRECHENDEN ANTISEREN IM PRAZIPITATIONSTEST UND IN DER KOMPLEMENTBINDUNGSREAKTION, ZEITSCHRIFT FUR IMMUNITATSFORSCHUNG UND EXPERIMENTELLE THERAPIE 125: 470 (1963).","journal-title":"ZEITSCHRIFT FUR IMMUNITATSFORSCHUNG UND EXPERIMENTELLE THERAPIE"},{"key":"e_1_2_1_16_1","first-page":"41","volume":"126","year":"1964","unstructured":"NIEDIECK, B, Z IMMUNITATSFORSCH 126: 41 (1964).","journal-title":"Z IMMUNITATSFORSCH"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00005072-197004000-00002","volume":"29","year":"1970","unstructured":"RAINE, C.S., EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - AN ULTRASTRUCTURAL STUDY OF EXPERIMENTAL DEMYELINATION IN-VITRO, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 29: 177 (1970).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_18_1","first-page":"273","volume":"13","year":"1969","unstructured":"RAPPORT, M.M., IMMUNOCHEMICAL REACTIONS OF LIPIDS, PROGRESS IN ALLERGY 13: 273 (1969).","journal-title":"PROGRESS IN ALLERGY"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1084\/jem.60.5.559","volume":"60","year":"1934","unstructured":"SCHWENTKER, F.F., The antibody response of rabbits to injections of emulsions and extracts of homologous brain, JOURNAL OF EXPERIMENTAL MEDICINE 60: 559 (1934).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0014-4886(68)90148-9","volume":"22","year":"1968","unstructured":"SEIL, F.J., IN VITRO DEMYELINATING ACTIVITY OF SERA FROM GUINEA PIGS SENSITIZED WITH WHOLE CNS AND WITH PURIFIED ENCEPHALITOGEN, EXPERIMENTAL NEUROLOGY 22: 545 (1968).","journal-title":"EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1471-4159.1972.tb01248.x","volume":"19","year":"1972","unstructured":"SILBERBERG, D, INCORPORATION OF RADIOACTIVE SULFATE INTO SULFATIDE DURING MYELINATION IN CULTURES OF RAT CEREBELLUM, JOURNAL OF NEUROCHEMISTRY 19: 11 (1972).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_22_1","first-page":"180","volume":"28","year":"1969","unstructured":"YONEZAWA, T, DEMYELINATING ANTIBODIES OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND PERIPHERAL NEURITIS REPRESENTED BY DEMYELINATING PATTERN IN VITRO, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 28: 180 (1969).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.183.4124.540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T20:11:05Z","timestamp":1705003865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.183.4124.540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,2,8]]},"references-count":22,"journal-issue":{"issue":"4124","published-print":{"date-parts":[[1974,2,8]]}},"alternative-id":["10.1126\/science.183.4124.540"],"URL":"https:\/\/doi.org\/10.1126\/science.183.4124.540","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,2,8]]}}}