{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:49:40Z","timestamp":1774676980371,"version":"3.50.1"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5017","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1991,7,19]]},"abstract":"<jats:p>\n            Mycosis fungoides, a rare form of cutaneous T cell leukemia\/lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T cell leukemia, which is associated with human T cell leukemia\/lymphoma virus type I (HTLV-I) infection. Cell lines were established from peripheral blood mononuclear cells (PBMC) of an HTLV-I-seronegative patient with mycosis fungoides. DNA hybridization analysis revealed the presence of HTLV-I-related sequences with unusual restriction endonuclease sites. Sequence analysis of subcloned fragments demonstrated the presence of a monoclonally integrated provirus with a 5.5-kilobase deletion involving large regions of\n            <jats:italic>gag<\/jats:italic>\n            and\n            <jats:italic>env<\/jats:italic>\n            and all of\n            <jats:italic>pol<\/jats:italic>\n            . Additional evidence for the presence of deleted proviruses was found by polymerase chain reaction (PCR) amplification of DNA from cutaneous lesions of five other HTLV-I-seronegative patients. The findings suggest that HTLV-I infection may be involved in the etiology of at least certain cases of mycosis fungoides.\n          <\/jats:p>","DOI":"10.1126\/science.1857968","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"317-320","source":"Crossref","is-referenced-by-count":137,"title":["Deleted HTLV-I Provirus in Blood and Cutaneous Lesions of Patients with Mycosis Fungoides"],"prefix":"10.1126","volume":"253","author":[{"given":"William W.","family":"Hall","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunren R.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Schneewind","sequence":"additional","affiliation":[{"name":"The Rockefeller University, New York, NY 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gosta","family":"R\u00f6upe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sahlgrens Hospital, Goteborg, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Vahlne","sequence":"additional","affiliation":[{"name":"Department of Clinical Virology, University of G\u00f6teborg, G\u00f6teborg, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"11","volume":"85","year":"1979","unstructured":"BRAUNFALCO, O, ACTA DERMATO-VENEREOLOGICA 85: 11 (1979).","journal-title":"ACTA DERMATO-VENEREOLOGICA"},{"key":"e_1_2_1_2_1","first-page":"797","volume":"119","year":"1983","unstructured":"BUECHNER, S.A., ARCHIVES OF DERMATOLOGY 119: 797 (1983).","journal-title":"ARCHIVES OF DERMATOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJM198308043090501","volume":"309","year":"1983","unstructured":"BUNN, P.A., CLINICAL COURSE OF RETROVIRUS-ASSOCIATED ADULT T-CELL LYMPHOMA IN THE UNITED-STATES, NEW ENGLAND JOURNAL OF MEDICINE 309: 257 (1983).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_4_1","first-page":"109","volume":"11","year":"1986","unstructured":"CLENDENNING, W.E., CLIN EXP DERMATOL 11: 109 (1986).","journal-title":"CLIN EXP DERMATOL"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90754-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00005792-197201000-00004","volume":"51","year":"1972","unstructured":"EPSTEIN, E.H., MYCOSIS-FUNGOIDES - SURVIVAL, PROGNOSTIC FEATURES, RESPONSE TO THERAPY, AND AUTOPSY FINDINGS, MEDICINE 51: 61 (1972).","journal-title":"MEDICINE"},{"key":"e_1_2_1_7_1","first-page":"3892","volume":"43","year":"1983","unstructured":"GALLO, R.C., ASSOCIATION OF THE HUMAN TYPE-C RETROVIRUS WITH A SUBSET OF ADULT T-CELL CANCERS, CANCER RESEARCH 43: 3892 (1983).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_8_1","first-page":"254","year":"1990","unstructured":"Hall, W. 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