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In contrast, intracerebral injection of less than 10\n            <jats:sup>3<\/jats:sup>\n            CTL caused disease and death when viral antigens were expressed on leptomeningial and choroid plexus cells of the nervous system. The neuronal cell line OBL21 expresses little or no major histocompatibility (MHC) class I surface glycoproteins and when infected with LCMV, resisted lysis by virus-specific CTLs. Expression of MHC heavy chain messenger RNA was limited, but \u03b2\n            <jats:sub>2<\/jats:sub>\n            -microglobulin messenger RNA and protein was made normally. OBL21 cells were made sensitive to CTL lysis by transfection with a fusion gene encoding another MHC class I molecule. Hence, neuronal cells probably evade immune surveillance by failing to express MHC class I molecules.\n          <\/jats:p>","DOI":"10.1126\/science.1891717","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"1283-1285","source":"Crossref","is-referenced-by-count":236,"title":["Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I Expression"],"prefix":"10.1126","volume":"253","author":[{"given":"Etienne","family":"Joly","sequence":"first","affiliation":[{"name":"Division of Virology, Department of Neuropharmacology, Scripps Clinic and Research Foundation, La Jolla, CA 92037."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Mucke","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Neuropharmacology, Scripps Clinic and Research Foundation, La Jolla, CA 92037."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B. 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