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The localization and discharge pattern of these cells indicate that cataplexy results from a triggering in waking of the neurons responsible for the suppression of muscle tone in REM sleep. However, most medullary cells were inactive during cataplexy but were active during REM sleep. These data demonstrate that cataplexy is a distinct behavioral state, differing from other sleep and waking states in its pattern of brainstem neuronal activity.<\/jats:p>","DOI":"10.1126\/science.1925546","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"1315-1318","source":"Crossref","is-referenced-by-count":123,"title":["Neuronal Activity in Narcolepsy: Identification of Cataplexy-Related Cells in the Medial Medulla"],"prefix":"10.1126","volume":"252","author":[{"given":"Jerome M.","family":"Siegel","sequence":"first","affiliation":[{"name":"Neurobiology Research, Veterans Affairs Medical Center, Sepulveda, CA 91343 and and Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Nienhuis","sequence":"additional","affiliation":[{"name":"Neurobiology Research, Veterans Affairs Medical Center, Sepulveda, CA 91343 and and Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M.","family":"Fahringer","sequence":"additional","affiliation":[{"name":"Neurobiology Research, Veterans Affairs Medical Center, Sepulveda, CA 91343 and and Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Paul","sequence":"additional","affiliation":[{"name":"Neurobiology Research, Veterans Affairs Medical Center, Sepulveda, CA 91343 and and Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyattam","family":"Shiromani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, San Diego Veterans Affairs Medical Center, and University of California, La Jolla, CA 92093."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Dement","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA 94305."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mignot","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA 94305."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Chiu","sequence":"additional","affiliation":[{"name":"Neurobiology Research, Veterans Affairs Medical Center, Sepulveda, CA 91343 and and Department of Psychiatry and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90024."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/sleep\/12.3.254","volume":"12","year":"1989","unstructured":"ALDRICH, M.S., EXACERBATION OF HUMAN CATAPLEXY BY PRAZOSIN, SLEEP 12: 254 (1989).","journal-title":"SLEEP"},{"key":"e_1_2_1_2_1","first-page":"199","year":"1985","unstructured":"Baker, T. 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