{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:27:14Z","timestamp":1792135634577,"version":"4.4.0"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4353","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1978,7,28]]},"abstract":"<jats:p>\n            Irradiation of solutions at\n            <jats:italic>p<\/jats:italic>\n            H 7 to\n            <jats:italic>p<\/jats:italic>\n            H 8.5 of orotic acid, orotidine, and orotidine 5\u2032-phosphate with light at 254 nanometers yields the corresponding uracil derivative via the singlet excited state. This reaction completes a plausible prebiotic synthesis of uracil and its derivatives starting from HCN as the only carbon source.\n          <\/jats:p>","DOI":"10.1126\/science.208152","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"361-362","source":"Crossref","is-referenced-by-count":21,"title":["Chemical Evolution from Hydrogen Cyanide: Photochemical Decarboxylation of Orotic Acid and Orotate Derivatives"],"prefix":"10.1126","volume":"201","author":[{"given":"J. P.","family":"Ferris","sequence":"first","affiliation":[{"name":"Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12181"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12181"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1246\/nikkashi1898.72.239","volume":"72","year":"1969","unstructured":"AZUMA, C, KOUGYOU KAGAKU ZASSHI 72: 239 (1969).","journal-title":"KOUGYOU KAGAKU ZASSHI"},{"key":"e_1_2_1_2_1","first-page":"430","volume":"1","year":"1970","unstructured":"AZUMA, C, SPEC REP PHOTOCHEM 1: 430 (1970).","journal-title":"SPEC REP PHOTOCHEM"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1021\/ja00428a035","volume":"98","year":"1976","unstructured":"BEAK, P, MECHANISM OF DECARBOXYLATION OF 1,3-DIMETHYLOROTIC ACID - MODEL FOR OROTIDINE 5'-PHOSPHATE DECARBOXYLASE, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 98: 3601 (1976).","journal-title":"JOURNAL OF THE AMERICAN CHEMICAL SOCIETY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0006-3002(60)91302-0","volume":"38","year":"1960","unstructured":"BEUKERS, R, THE EFFECT OF PARAMAGNETIC SUBSTANCES ON THE CONVERSION OF SOME PYRIMIDINES BY ULTRAVIOLET RADIATION, BIOCHIMICA ET BIOPHYSICA ACTA 38: 573 (1960).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1751-1097.1972.tb06224.x","volume":"15","year":"1972","unstructured":"CHARLIER, M, PHOTOCHEMICAL REACTIONS OF AROMATIC KETONES WITH NUCLEIC-ACIDS AND THEIR COMPONENTS .1. PURINE AND PYRIMIDINE BASES AND NUCLEOSIDES, PHOTOCHEMISTRY AND PHOTOBIOLOGY 15: 71 (1972).","journal-title":"PHOTOCHEMISTRY AND PHOTOBIOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1139\/v72-324","volume":"50","year":"1972","unstructured":"CHAU, F, PHOTOLYSIS OF BENZOIC-ACID IN VAPOR-PHASE, CANADIAN JOURNAL OF CHEMISTRY 50: 2017 (1972).","journal-title":"CANADIAN JOURNAL OF CHEMISTRY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1021\/j100637a018","volume":"77","year":"1973","unstructured":"FENSTER, A, TEMPERATURE STUDIES FOR QUENCHING OF PYRIMIDINE TRIPLET-STATES, JOURNAL OF PHYSICAL CHEMISTRY 77: 2246 (1973).","journal-title":"JOURNAL OF PHYSICAL CHEMISTRY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0303-2647(77)90015-6","volume":"9","year":"1977","unstructured":"FERRIS, J.P., CHEMICAL EVOLUTION .29. PYRIMIDINES FROM HYDROGEN-CYANIDE, BIOSYSTEMS 9: 81 (1977).","journal-title":"BIOSYSTEMS"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF01733839","volume":"11","year":"1978","unstructured":"Ferris, J. P., Journal of Molecular Evolution 11: 293 (1978).","journal-title":"Journal of Molecular Evolution"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-291X(68)90706-7","volume":"30","year":"1968","unstructured":"GREENSTOCK, C.L., PHOTOSENSITIZED DIMERIZATION OF PYRIMIDINES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 30: 21 (1968).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_11_1","first-page":"518","volume":"235","year":"1956","unstructured":"HATCHARD, C.G., A NEW SENSITIVE CHEMICAL ACTINOMETER .2. POTASSIUM FERRIOXALATE AS A STANDARD CHEMICAL ACTINOMETER, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES 235: 518 (1956).","journal-title":"PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES"},{"key":"e_1_2_1_12_1","first-page":"153","volume":"31","year":"1945","unstructured":"HOROWITZ, N.H., ON THE EVOLUTION OF BIOCHEMICAL SYNTHESES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 31: 153 (1945).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_13_1","first-page":"7","year":"1969","unstructured":"JENCKS, W.P., CATALYSIS CHEM ENZYM: 7 (1969).","journal-title":"CATALYSIS CHEM ENZYM"},{"key":"e_1_2_1_14_1","first-page":"237","year":"1976","unstructured":"KIMURA, T, CHEMISTRY LETTERS: 237 (1976).","journal-title":"CHEMISTRY LETTERS"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF01739102","volume":"8","year":"1976","unstructured":"MCCLENDON, J.H., ELEMENTAL ABUNDANCE AS A FACTOR IN ORIGINS OF MINERAL NUTRIENT-REQUIREMENTS, JOURNAL OF MOLECULAR EVOLUTION 8: 175 (1976).","journal-title":"JOURNAL OF MOLECULAR EVOLUTION"},{"key":"e_1_2_1_16_1","unstructured":"MILLER S.L. ORIGINS LIFE EARTH (1974)."},{"key":"e_1_2_1_17_1","first-page":"223","volume":"30","year":"1967","unstructured":"SANCHEZ, R.A., STUDIES IN PREBIOTIC SYNTHESIS .2. SYNTHESIS OF PURINE PRECURSORS AND AMINO ACIDS FROM AQUEOUS HYDROGEN CYANIDE, JOURNAL OF MOLECULAR BIOLOGY 30: 223 (1967).","journal-title":"JOURNAL OF MOLECULAR BIOLOGY"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1751-1097.1965.tb07914.x","volume":"4","year":"1965","unstructured":"STUMPF, E, PHOTOCHEMISTRY AND PHOTOBIOLOGY 4: 719 (1965).","journal-title":"PHOTOCHEMISTRY AND PHOTOBIOLOGY"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1246\/bcsj.43.3637","volume":"43","year":"1970","unstructured":"TAKENCHI, F, PHOTOCHEMICAL REACTIONS OF NICOTINIC ACID IN AQUEOUS AND ETHANOL SOLUTIONS, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 43: 3637 (1970).","journal-title":"BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/0006-2952(76)90425-1","volume":"25","year":"1976","unstructured":"TAX, WJM, MECHANISM OF ALLOPURINOL-MEDIATED INHIBITION AND STABILIZATION OF HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE AND OROTIDINE PHOSPHATE DECARBOXYLASE, BIOCHEMICAL PHARMACOLOGY 25: 2025 (1976).","journal-title":"BIOCHEMICAL PHARMACOLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.208152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T02:13:41Z","timestamp":1705025621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.208152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7,28]]},"references-count":20,"journal-issue":{"issue":"4353","published-print":{"date-parts":[[1978,7,28]]}},"alternative-id":["10.1126\/science.208152"],"URL":"https:\/\/doi.org\/10.1126\/science.208152","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,7,28]]}}}