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The complex ligand so formed has specificity for a particular part of T cell receptors, V\n            <jats:sub>\u03b2<\/jats:sub>\n            , and by engaging V\n            <jats:sub>\u03b2<\/jats:sub>\n            can stimulate many T cells. It is likely that some or all of the pathological effects of these toxins are caused by their ability to activate quickly so many T cells. It is also possible that encounters with such toxins have caused mice, at least, to evolve mechanisms for varying their T cell V\n            <jats:sub>\u03b2<\/jats:sub>\n            repertoires, such that they are less susceptible to attack by the toxins.\n          <\/jats:p>","DOI":"10.1126\/science.2185544","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:14Z","timestamp":1160086214000},"page":"705-711","source":"Crossref","is-referenced-by-count":1353,"title":["The Staphylococcal Enterotoxins and Their Relatives"],"prefix":"10.1126","volume":"248","author":[{"given":"P","family":"Marrack","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, and Departments of Biochemistry, Microbiology, and Immunology, and Medicine, University of Colorado Health Sciences Center, Denver, CO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kappler","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, and Departments of Biochemistry, Microbiology, and Immunology, and Medicine, University of Colorado Health Sciences Center, Denver, CO."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1084\/jem.165.4.1113","volume":"165","year":"1987","unstructured":"ABE, R, CLONAL ANALYSIS OF THE MLS SYSTEM - A REAPPRAISAL OF POLYMORPHISM AND ALLELISM AMONG MLSA, MLSC, AND MLSD, JOURNAL OF EXPERIMENTAL MEDICINE 165: 1113 (1987).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.4049\/jimmunol.138.2.373","volume":"138","year":"1987","unstructured":"ABE, R, T-CELL RECOGNITION OF MLS - T-CELL CLONES DEMONSTRATE POLYMORPHISM BETWEEN MLSA, MLSC, AND MLSD, JOURNAL OF IMMUNOLOGY 138: 373 (1987).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/317359a0","volume":"317","year":"1985","unstructured":"BABBITT, B.P., BINDING OF IMMUNOGENIC PEPTIDES TO IA HISTOCOMPATIBILITY MOLECULES, NATURE 317: 359 (1985).","journal-title":"NATURE"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000234204","volume":"82","year":"1987","unstructured":"BAMBERGER, U, ANTIIDIOTYPIC ANTIBODIES AS STAPHYLOCOCCAL-ENTEROTOXIN RECEPTOR PROBES ON MONKEY MAST-CELLS, INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY 82: 272 (1987).","journal-title":"INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000234209","volume":"82","year":"1987","unstructured":"SCHEUBER, P. 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