{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:23:06Z","timestamp":1790036586062,"version":"4.0.1"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4963","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1990,6,29]]},"abstract":"<jats:p>The normal function of vertebrate photoreceptor cells depends on multiple interactions and transfer of substances between the photoreceptors and the retinal pigment epithelium (RPE), but the mechanisms of these interactions are poorly understood. Many are thought to be mediated by the interphotoreceptor matrix (IPM), a complex extracellular matrix that surrounds the photoreceptors and lies between them and the RPE. Histochemical, immunocytochemical, and lectin probes for several IPM constituents revealed that components of the IPM in the rat undergo a major shift in distribution or molecular conformation after the transition between light and dark. In the light, various IPM constituents concentrated in bands at the apical and basal regions of the outer segment zone; in the dark, they distributed much more uniformly throughout the zone. The change in IPM distribution was triggered by the light-dark transition; it was not a circadian event, and it was not driven by a systemic factor. The light-evoked change in IPM distribution may facilitate the transfer of substances between the photoreceptors and the RPE.<\/jats:p>","DOI":"10.1126\/science.2194288","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:14Z","timestamp":1160086214000},"page":"1633-1636","source":"Crossref","is-referenced-by-count":66,"title":["Light-Evoked Changes in the Interphotoreceptor Matrix"],"prefix":"10.1126","volume":"248","author":[{"given":"Fumiyuki","family":"Uehara","sequence":"first","affiliation":[{"name":"Departments of Anatomy and Ophthalmology and Beckman Vision Center, University of California, San Francisco, CA 94143."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Matthes","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Ophthalmology and Beckman Vision Center, University of California, San Francisco, CA 94143."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Yasumura","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Ophthalmology and Beckman Vision Center, University of California, San Francisco, CA 94143."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"LaVail","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Ophthalmology and Beckman Vision Center, University of California, San Francisco, CA 94143."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/S0006-291X(82)80091-0","volume":"108","year":"1982","unstructured":"ADLER, A.J., RETINOL-BINDING PROTEINS IN BOVINE INTERPHOTORECEPTOR MATRIX, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 108: 1601 (1982).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_2_1","first-page":"65","year":"1985","unstructured":"Adler, A. J., The Interphotoreceptor Matrix in Health and Disease: 65 (1985).","journal-title":"The Interphotoreceptor Matrix in Health and Disease"},{"key":"e_1_2_1_3_1","unstructured":"Pearse A. G. E. Histochemistry: Theoretical and Applied (1968)."},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0278-4327(88)90004-1","article-title":"Regulation of rhythmic photoreceptor metabolism: A role for post-receptoral neurons","volume":"7","year":"1988","unstructured":"Besharse, J. C., Regulation of rhythmic photoreceptor metabolism: A role for post-receptoral neurons, Progress in Retinal Research 7: 21 (1988).","journal-title":"Progress in Retinal Research"},{"key":"e_1_2_1_5_1","first-page":"289","volume":"25","year":"1984","unstructured":"BORGULA, G.A., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 25 Supplement: 289 (1984).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0042-6989(89)90054-0","volume":"29","year":"1989","unstructured":"BORGULA, G.A., LIGHT-EVOKED CHANGES IN EXTRACELLULAR PH IN FROG RETINA, VISION RESEARCH 29: 1069 (1989).","journal-title":"VISION RESEARCH"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3101175"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.241.4867.846"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0014-4835(76)90182-2","volume":"22","year":"1976","unstructured":"BRIDGES, CDB, VITAMIN-A AND ROLE OF PIGMENT EPITHELIUM DURING BLEACHING AND REGENERATION OF RHODOPSIN IN FROG EYE, EXPERIMENTAL EYE RESEARCH 22: 435 (1976).","journal-title":"EXPERIMENTAL EYE RESEARCH"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"Bridges C. D. B. The Interphotoreceptor Matrix in Health and Disease (1985).","DOI":"10.1097\/00006324-198606000-00017"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1083\/jcb.97.3.703","volume":"97","year":"1983","unstructured":"BUNTMILAM, A.H., IMMUNOCYTOCHEMICAL LOCALIZATION OF 2 RETINOID-BINDING PROTEINS IN VERTEBRATE RETINA, JOURNAL OF CELL BIOLOGY 97: 703 (1983).","journal-title":"JOURNAL OF CELL BIOLOGY"},{"key":"e_1_2_1_12_1","first-page":"7","volume":"30","year":"1989","unstructured":"CHADER, G.J., INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP) - A MODEL PROTEIN FOR MOLECULAR BIOLOGICAL AND CLINICALLY RELEVANT STUDIES, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 30: 7 (1989).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0021-9797(76)90209-5","volume":"57","year":"1976","unstructured":"COMPER, W.D., DIFFUSION POTENTIALS OF POLYELECTROLYTES AND THEIR POSSIBLE RELATIONSHIP TO BIOLOGICAL ELECTROCHEMICAL PHENOMENA, JOURNAL OF COLLOID AND INTERFACE SCIENCE 57: 345 (1976).","journal-title":"JOURNAL OF COLLOID AND INTERFACE SCIENCE"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1152\/physrev.1978.58.1.255","volume":"58","year":"1978","unstructured":"COMPER, W.D., PHYSIOLOGICAL FUNCTION OF CONNECTIVE-TISSUE POLYSACCHARIDES, PHYSIOLOGICAL REVIEWS 58: 255 (1978).","journal-title":"PHYSIOLOGICAL REVIEWS"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/188114a0","volume":"188","year":"1960","unstructured":"DOWLING, J.E., CHEMISTRY OF VISUAL ADAPTATION IN THE RAT, NATURE 188: 114 (1960).","journal-title":"NATURE"},{"key":"e_1_2_1_16_1","first-page":"775","volume":"26","year":"1985","unstructured":"EISENFELD, A.J., IMMUNOCYTOCHEMICAL LOCALIZATION OF INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN IN DEVELOPING NORMAL AND RCS RAT RETINAS, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 26: 775 (1985).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0006-3495(85)83949-7","volume":"47","year":"1985","unstructured":"FRAMBACH, D.A., A PHOTOGRAMMETRIC METHOD TO MEASURE FLUID MOVEMENT ACROSS ISOLATED FROG RETINAL-PIGMENT EPITHELIUM, BIOPHYSICAL JOURNAL 47: 547 (1985).","journal-title":"BIOPHYSICAL JOURNAL"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.1021\/bi00398a059","volume":"26","year":"1987","unstructured":"FULTON, B.S., BIOSYNTHESIS OF 11-CIS-RETINOIDS AND RETINYL ESTERS BY BOVINE PIGMENT-EPITHELIUM MEMBRANES, BIOCHEMISTRY 26: 7938 (1987).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_19_1","first-page":"5557","volume":"77","year":"1980","unstructured":"Gold, G. H., Proceedings of the National Academy of Sciences of the United States of America 77: 5557 (1980).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_20_1","first-page":"1150","volume":"83","year":"1986","unstructured":"GOLD, G.H., PLASMA-MEMBRANE CALCIUM FLUXES IN INTACT RODS ARE INCONSISTENT WITH THE CALCIUM HYPOTHESIS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 1150 (1986).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1083\/jcb.99.6.2092","volume":"99","year":"1984","unstructured":"GONZALEZFERNAND.F, AN EXTRACELLULAR RETINOL-BINDING GLYCOPROTEIN IN THE EYES OF MUTANT RATS WITH RETINAL DYSTROPHY - DEVELOPMENT, LOCALIZATION, AND BIOSYNTHESIS, JOURNAL OF CELL BIOLOGY 99: 2092 (1984).","journal-title":"JOURNAL OF CELL BIOLOGY"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0021-9258(19)85031-7","volume":"264","year":"1989","unstructured":"HO, MTP, MECHANISM OF VITAMIN-A MOVEMENT BETWEEN ROD OUTER SEGMENTS, INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN, AND LIPOSOMES, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 928 (1989).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_23_1","first-page":"59","volume":"9","year":"1989","unstructured":"HOLLYFIELD, J. G., RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 9: 59 (1989).","journal-title":"RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/298848a0","volume":"298","year":"1982","unstructured":"LAI, Y.L., INTERPHOTORECEPTOR RETINOL-BINDING PROTEINS - POSSIBLE TRANSPORT VEHICLES BETWEEN COMPARTMENTS OF THE RETINA, NATURE 298: 848 (1982).","journal-title":"NATURE"},{"key":"e_1_2_1_25_1","first-page":"658","volume":"21","year":"1981","unstructured":"LAVAIL, M.M., THE INTERPHOTORECEPTOR MATRIX IN RATS WITH INHERITED RETINAL DYSTROPHY, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 21: 658 (1981).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_26_1","first-page":"407","volume":"19","year":"1980","unstructured":"LAVAIL, M.M., CIRCADIAN NATURE OF ROD OUTER SEGMENT DISK SHEDDING IN THE RAT, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 19: 407 (1980).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.982063"},{"key":"e_1_2_1_28_1","unstructured":"Lillie R. D. Histopathologic Technic and Practical Histochemistry (1976)."},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/0042-6989(82)90210-3","volume":"22","year":"1982","unstructured":"LIOU, G.I., VITAMIN-A TRANSPORT BETWEEN RETINA AND PIGMENT-EPITHELIUM - AN INTERSTITIAL PROTEIN CARRYING ENDOGENOUS RETINOL (INTERSTITIAL RETINOL-BINDING PROTEIN), VISION RESEARCH 22: 1457 (1982).","journal-title":"VISION RESEARCH"},{"key":"e_1_2_1_30_1","first-page":"2111","volume":"79","year":"1982","unstructured":"Miller, S. S., Proceedings of the National Academy of Sciences of the United States of America 79: 2111 (1982).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/S0021-9258(19)42646-X","volume":"249","year":"1974","unstructured":"NAGATA, Y, WHEAT-GERM AGGLUTININ - MOLECULAR CHARACTERISTICS AND SPECIFICITY FOR SUGAR BINDING, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 3116 (1974).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1152\/jn.1976.39.5.1117","volume":"39","year":"1976","unstructured":"OAKLEY, B, CORRELATION OF LIGHT-INDUCED-CHANGES IN RETINAL EXTRACELLULAR POTASSIUM CONCENTRATION WITH C-WAVE OF ELECTRORETINOGRAM, JOURNAL OF NEUROPHYSIOLOGY 39: 1117 (1976).","journal-title":"JOURNAL OF NEUROPHYSIOLOGY"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3109\/02713688608995180","volume":"5","year":"1986","unstructured":"PORRELLO, K, IMMUNOCYTOCHEMICAL LOCALIZATION OF CHONDROITIN SULFATES IN THE INTERPHOTORECEPTOR MATRIX OF THE NORMAL AND DYSTROPHIC RAT RETINA, CURRENT EYE RESEARCH 5: 981 (1986).","journal-title":"CURRENT EYE RESEARCH"},{"key":"e_1_2_1_34_1","first-page":"1577","volume":"27","year":"1986","unstructured":"PORRELLO, K, HISTOCHEMICAL-DEMONSTRATION OF SPATIAL HETEROGENEITY IN THE INTERPHOTORECEPTOR MATRIX OF THE RAT RETINA, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 27: 1577 (1986).","journal-title":"INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE"},{"key":"e_1_2_1_35_1","first-page":"638","volume":"30","year":"1989","unstructured":"PORRELLO, K, INVEST OPHTH VIS SCI 30: 638 (1989).","journal-title":"INVEST OPHTH VIS SCI"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3136548"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1152\/jn.1980.44.5.897","volume":"44","year":"1980","unstructured":"STEINBERG, R.H., LIGHT-EVOKED CHANGES IN [K+]0 IN RETINA OF INTACT CAT EYE, JOURNAL OF NEUROPHYSIOLOGY 44: 897 (1980).","journal-title":"JOURNAL OF NEUROPHYSIOLOGY"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-4835(86)80090-2","volume":"43","year":"1986","unstructured":"UEHARA, F, TWO-DIMENSIONAL GEL-ELECTROPHORETIC ANALYSIS OF LECTIN RECEPTORS IN THE BOVINE INTERPHOTORECEPTOR MATRIX, EXPERIMENTAL EYE RESEARCH 43: 227 (1986).","journal-title":"EXPERIMENTAL EYE RESEARCH"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jnr.490200216","volume":"20","year":"1988","unstructured":"WHELAN, J.P., LIGHT-DEPENDENT SUBCELLULAR MOVEMENT OF PHOTORECEPTOR PROTEINS, JOURNAL OF NEUROSCIENCE RESEARCH 20: 263 (1988).","journal-title":"JOURNAL OF NEUROSCIENCE RESEARCH"},{"key":"e_1_2_1_40_1","unstructured":"Zinn K. M. The Retinal Pigment Epithelium (1979)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.2194288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T09:18:02Z","timestamp":1705051082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.2194288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6,29]]},"references-count":40,"journal-issue":{"issue":"4963","published-print":{"date-parts":[[1990,6,29]]}},"alternative-id":["10.1126\/science.2194288"],"URL":"https:\/\/doi.org\/10.1126\/science.2194288","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6,29]]}}}