{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:06:45Z","timestamp":1789751205974,"version":"4.0.1"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4981","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1990,11,2]]},"abstract":"<jats:p>\n            The function of the c-\n            <jats:italic>myc<\/jats:italic>\n            gene and its role in tumorigenesis are poorly understood. In order to elucidate the role of c-\n            <jats:italic>myc<\/jats:italic>\n            oncogene activation in B cell malignancy, the phenotypic changes caused by the expression of c-\n            <jats:italic>myc<\/jats:italic>\n            oncogenes in human B lymphoblastoid cells immortalized by Epstein-Barr virus were analyzed. C-\n            <jats:italic>myc<\/jats:italic>\n            oncogenes caused the down-regulation of lymphocyte function-associated antigen-1 (LFA-1) adhesion molecules (\u03b1\n            <jats:sub>L<\/jats:sub>\n            \/ \u03b2\n            <jats:sub>2<\/jats:sub>\n            integrin) and loss of homotypic B cell adhesion in vitro. Down-regulation of LFA-1 occurred by (i) posttranscriptional modulation of LFA-1 \u03b1\n            <jats:sub>L<\/jats:sub>\n            -chain RNA soon after acute c-\n            <jats:italic>myc<\/jats:italic>\n            induction, and (ii) transcriptional modulation in cells that chronically express c-\n            <jats:italic>myc<\/jats:italic>\n            oncogenes. Analogous reductions in LFA-1 expression were detectable in Burkitt lymphoma cells carrying activated c-\n            <jats:italic>myc<\/jats:italic>\n            oncogenes. Since LFA-1 is involved in B cell adhesion to cytotoxic T cells, natural killer cells, and vascular endothelium, these results imply functions for c-\n            <jats:italic>myc<\/jats:italic>\n            in normal B cell development and lymphomagenesis.\n          <\/jats:p>","DOI":"10.1126\/science.2237417","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:14Z","timestamp":1160086214000},"page":"682-686","source":"Crossref","is-referenced-by-count":106,"title":["Down-regulation of LFA-1 Adhesion Receptors by C-\n            <i>myc<\/i>\n            Oncogene in Human B Lymphoblastoid Cells"],"prefix":"10.1126","volume":"250","author":[{"given":"Giorgio","family":"Inghirami","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Grignani","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Sternas","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigia","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalla-Favera","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"2012","volume":"10","year":"1990","unstructured":"AKESON, R, N-MYC DOWN REGULATES NEURAL CELL-ADHESION MOLECULE EXPRESSION IN RAT NEUROBLASTOMA, MOLECULAR AND CELLULAR BIOLOGY 10: 2012 (1990).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/321702a0","volume":"321","year":"1986","unstructured":"BENTLEY, D.L., A BLOCK TO ELONGATION IS LARGELY RESPONSIBLE FOR DECREASED TRANSCRIPTION OF C-MYC IN DIFFERENTIATED HL60 CELLS, NATURE 321: 702 (1986).","journal-title":"NATURE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0092-8674(86)90509-X","volume":"47","year":"1986","unstructured":"BERNARDS, R, N-MYC AMPLIFICATION CAUSES DOWN-MODULATION OF MHC CLASS-I ANTIGEN EXPRESSION IN NEUROBLASTOMA, CELL 47: 667 (1986).","journal-title":"CELL"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.cb.03.110187.001143","volume":"3","year":"1987","unstructured":"BUCK, C.A., CELL-SURFACE RECEPTORS FOR EXTRACELLULAR-MATRIX MOLECULES, ANNUAL REVIEW OF CELL BIOLOGY 3: 179 (1987).","journal-title":"ANNUAL REVIEW OF CELL BIOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3020687"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3685977"},{"key":"e_1_2_1_7_1","first-page":"533","volume":"2","year":"1987","unstructured":"CLAYBERGER, C, ABSENCE OF CELL-SURFACE LFA-1 AS A MECHANISM OF ESCAPE FROM IMMUNOSURVEILLANCE, LANCET 2: 533 (1987).","journal-title":"LANCET"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.ge.20.120186.002045","volume":"20","year":"1986","unstructured":"COLE, M.D., THE MYC ONCOGENE - 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