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The binding is inhibited by low concentrations of \u03b2-endorphin and its D-alanine\n            <jats:sup>2<\/jats:sup>\n            derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, \u03b2-lipotropin, adrenocorticotrophic hormone, or \u03b1-melanocyte-stimulating hormone; this suggests the existence of a specific, nonopiate binding site (receptor) for \u03b2-endorphin. The carboxy-terminal region of \u03b2-endorphin is essential for this binding activity, since \u03b1-endorphin is not active. \u03b2-Endorphin may be a circulating hormone with peripheral physiological effects that are not primarily mediated through interactions with opiate or enkephalin receptors.\n          <\/jats:p>","DOI":"10.1126\/science.224457","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:39:42Z","timestamp":1160066382000},"page":"1033-1035","source":"Crossref","is-referenced-by-count":368,"title":["Specific Nonopiate Receptors for \u03b2-Endorphin"],"prefix":"10.1126","volume":"205","author":[{"given":"Eli","family":"Hazum","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwen-Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.185694"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30115-1"},{"key":"e_1_2_1_3_1","first-page":"91","volume":"16","year":"1979","unstructured":"CHANG, K.J., MULTIPLE OPIATE RECEPTORS - 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