{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:18:48Z","timestamp":1791091128723,"version":"4.1.0"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4955","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1990,5,4]]},"abstract":"<jats:p>\n            The\n            <jats:italic>Drosophila<\/jats:italic>\n            <jats:italic>Shaker<\/jats:italic>\n            gene on the X chromosome has three sister genes,\n            <jats:italic>Shal<\/jats:italic>\n            ,\n            <jats:italic>Shab<\/jats:italic>\n            , and\n            <jats:italic>Shaw<\/jats:italic>\n            , which map to the second and third chromosomes. This extended gene family encodes voltage-gated potassium channels with widely varying kinetics (rate of macroscopic current activation and inactivation) and voltage sensitivity of steady-state inactivation. The differences in the currents of the various gene products are greater than the differences produced by alternative splicing of the\n            <jats:italic>Shaker<\/jats:italic>\n            gene. In\n            <jats:italic>Drosophila<\/jats:italic>\n            , the transient (A current) subtype of the potassium channel (\n            <jats:italic>Shaker<\/jats:italic>\n            and\n            <jats:italic>Shal<\/jats:italic>\n            ) and the delayed-rectifier subtype (\n            <jats:italic>Shab<\/jats:italic>\n            and\n            <jats:italic>Shaw<\/jats:italic>\n            ) are encoded by homologous genes, and there is more than one gene for each subtype of channel. Homologs of\n            <jats:italic>Shaker<\/jats:italic>\n            ,\n            <jats:italic>Shal<\/jats:italic>\n            ,\n            <jats:italic>Shab<\/jats:italic>\n            , and\n            <jats:italic>Shaw<\/jats:italic>\n            are present in mammals; each\n            <jats:italic>Drosophila<\/jats:italic>\n            potassium-channel gene may be represented as a multigene subfamily in mammals.\n          <\/jats:p>","DOI":"10.1126\/science.2333511","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:14Z","timestamp":1160086214000},"page":"599-603","source":"Crossref","is-referenced-by-count":252,"title":["K\n            <sup>+<\/sup>\n            Current Diversity Is Produced by an Extended Gene Family Conserved in\n            <i>Drosophila<\/i>\n            and Mouse"],"prefix":"10.1126","volume":"248","author":[{"given":"Aguan","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Covarrubias","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Salkoff","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110."},{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/331114a0","volume":"331","year":"1988","unstructured":"AGNEW, W.S., MOLECULAR NEUROBIOLOGY - 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