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Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4\n            <jats:sup>+<\/jats:sup>\n            peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III\/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.\n          <\/jats:p>","DOI":"10.1126\/science.2412295","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:42:50Z","timestamp":1160077370000},"page":"71-73","source":"Crossref","is-referenced-by-count":481,"title":["Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III"],"prefix":"10.1126","volume":"230","author":[{"given":"N. 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